Muscle Tightness and Twitching: Neurological Insights - Neurology

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Whole body twitching, with tightness and numbness in the hands and feet?


Hello, Doctor Gao.
I previously asked you about the pain in my left leg, which has persisted for two years from my thigh to my calf.
The symptoms include tightness, pain, and soreness, and I feel uncomfortable every day.
I have undergone numerous tests at the hospital, including electromyography and nerve conduction studies, all of which came back normal, with the last test done in November.
Recently, I have started experiencing discomfort in my left hand, particularly in my index finger, which appears to have a noticeable indentation on the fingertip.
It feels strange and painful, and I also experience tightness and pain when stretching.
My right hand has begun to exhibit similar sensations.
However, when I visited the hospital, they advised me to just observe.
I made a mistake last time; it is indeed the fingertip of my index finger that has a clear indentation, and my right hand has started to show a similar indentation, which looks different from a typical appearance.
Additionally, I often experience twitching in various parts of my body.
Doctor Gao, could you please advise on what kind of examinations I should pursue? Is this atrophy?

jerry, 30~39 year old female. Ask Date: 2016/02/09

Dr. Gao Chunde reply Neurology


Electromyography (EMG) primarily examines issues related to peripheral nerve and muscle diseases.
If the results are normal, then motor neuron diseases (such as amyotrophic lateral sclerosis) or myopathies are not considered at this time.
Symptoms such as tightness, pain, and soreness are more indicative of movement disorders, such as conditions related to Parkinson's disease, dystonia, or issues associated with the cerebellum.
Regarding the fingers, I personally have rarely encountered indentations or atrophy related to neurological diseases, so I am unable to provide an opinion at this moment.

Reply Date: 2016/02/09

More Info


Hello! It sounds like you are experiencing a complex set of symptoms that can be quite distressing. Muscle tightness, twitching, and discomfort in various parts of the body, especially when accompanied by changes in appearance like the indentation you mentioned in your fingers, can indeed raise concerns about underlying neurological or muscular issues.
First, let’s break down your symptoms. The persistent pain and tightness in your left leg over the past two years, along with the recent discomfort in your fingers, could suggest a few different possibilities. Given that your previous electromyography (EMG) and nerve conduction studies have returned normal results, it is reassuring that there is no immediate evidence of significant nerve damage or muscle disease. However, the presence of muscle twitching (also known as fasciculations) and the changes in your fingers could indicate a few different conditions that warrant further investigation.

1. Muscle Overuse or Strain: Chronic muscle tightness and pain can sometimes be attributed to overuse or strain, especially if you have been engaging in activities that put stress on those muscle groups. This can lead to muscle fatigue and discomfort, which may also explain the twitching.

2. Neuromuscular Disorders: While your EMG results were normal, neuromuscular disorders can sometimes present with subtle symptoms that may not be easily detected in initial tests. Conditions like myasthenia gravis or even early signs of motor neuron diseases can sometimes present with muscle weakness and twitching. However, these conditions typically have additional symptoms that would be more pronounced.

3. Anxiety and Stress: Psychological factors can also play a significant role in muscle tension and twitching. Anxiety can lead to muscle tightness and spasms, which might explain some of your symptoms. If you find that your symptoms worsen during stressful periods, this could be a contributing factor.

4. Nutritional Deficiencies: Deficiencies in certain vitamins and minerals, particularly magnesium, potassium, and calcium, can lead to muscle cramps, spasms, and twitching. It might be worthwhile to evaluate your diet or consider supplementation if you suspect this could be an issue.

5. Possible Atrophy: The indentation you mentioned in your fingers could suggest some degree of muscle atrophy, which is a reduction in muscle mass. This can occur due to disuse or neurological conditions. It’s important to have this evaluated by a healthcare professional who can assess for any signs of muscle wasting or weakness.

Given these considerations, I would recommend the following steps:
- Follow-Up with a Neurologist: Since you are experiencing a combination of symptoms that could be neurological in nature, a follow-up with a neurologist may be beneficial. They can perform a thorough clinical examination and may recommend additional tests, such as MRI scans or further EMG studies, to rule out any underlying conditions.

- Physical Therapy: Engaging in physical therapy could help address muscle tightness and improve strength and flexibility. A physical therapist can provide exercises tailored to your specific needs and help alleviate discomfort.

- Nutritional Assessment: Consider consulting with a nutritionist to evaluate your dietary intake and ensure you are meeting your nutritional needs, particularly for muscle health.

- Stress Management Techniques: If anxiety is a contributing factor, exploring stress management techniques such as mindfulness, yoga, or cognitive behavioral therapy could be beneficial.

In summary, while your previous tests have been normal, the persistence of your symptoms warrants further investigation. It’s essential to communicate openly with your healthcare providers about your concerns and symptoms to ensure a comprehensive approach to your health. Wishing you the best in your journey toward understanding and managing your symptoms!

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