Can Hyperthyroidism and Hypothyroidism Medications Be Taken Together? - Internal Medicine

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Can medications for hyperthyroidism and hypothyroidism be taken simultaneously?


This year, I experienced a relapse of hyperthyroidism.
After three months of medication, I had a blood test, and the results showed that only one item was outside the standard range.
I forgot the name of that item, but I remember that the standard value was <10, and my result was 21.2.
The doctor mentioned that my neck needed to reduce swelling, so he adjusted my medication by adding ELTROXIN 0.1 mg tablet once a day to my existing regimen of TAPAZOLE, which I take twice a day.
I noticed that the medication information for ELTROXIN states it is used to treat hypothyroidism, which raised my concern: why am I taking a medication for hyperthyroidism (TAPAZOLE) and a medication for hypothyroidism (ELTROXIN) at the same time? Are we trying to treat hyperthyroidism or hypothyroidism? I would greatly appreciate your explanation.

Chen, 30~39 year old female. Ask Date: 2002/07/30

Dr. Yang Hongzhi reply Internal Medicine


Reply to Chen Minhua: Tapazole is used to reduce thyroid function, and sometimes thyroid function may drop too low.
At this point, there are two methods to adjust: one is to lower the dose of Tapazole, and the other is to keep the Tapazole dose the same while adding Eltroxin to supplement thyroid function.
Both methods are viable options.

Reply Date: 2002/07/30

More Info


When it comes to managing thyroid conditions, particularly hyperthyroidism and hypothyroidism, the use of medications can sometimes seem contradictory. In your case, you are taking Tapazole (methimazole), which is used to treat hyperthyroidism, alongside Eltroxin (levothyroxine), which is prescribed for hypothyroidism. This combination may raise questions about the rationale behind using medications that target opposite thyroid conditions.

To clarify, hyperthyroidism is characterized by an overproduction of thyroid hormones, leading to symptoms such as weight loss, increased heart rate, anxiety, and heat intolerance. Conversely, hypothyroidism occurs when the thyroid gland does not produce enough hormones, resulting in symptoms like fatigue, weight gain, depression, and cold intolerance.
In your situation, the adjustment of your medication regimen likely reflects a nuanced approach to managing your thyroid levels. The fact that your doctor has prescribed both medications suggests that they are addressing different aspects of your thyroid function. Here are a few key points to consider:
1. Thyroid Hormone Levels: The thyroid gland produces two primary hormones, T3 (triiodothyronine) and T4 (thyroxine). In hyperthyroidism, there is an excess of these hormones, while in hypothyroidism, there is a deficiency. Your doctor may have identified that while you are being treated for hyperthyroidism, there may be fluctuations in your hormone levels that necessitate the addition of levothyroxine to stabilize your overall thyroid function.

2. Feedback Mechanism: The endocrine system operates on a feedback mechanism. When you take Tapazole, it inhibits the production of thyroid hormones. However, if your body’s levels drop too low, it can trigger a compensatory response that may lead to symptoms of hypothyroidism. By introducing Eltroxin, your doctor aims to ensure that your body has sufficient thyroid hormone levels to function properly, even while managing hyperthyroidism.

3. Monitoring and Adjustment: It is crucial to have regular monitoring of your thyroid hormone levels (TSH, T3, and T4) to ensure that the dosages of both medications are appropriate. Your healthcare provider will likely adjust the dosages based on your lab results and clinical symptoms. This careful monitoring helps to prevent the potential side effects of either condition being exacerbated.

4. Individualized Treatment: Thyroid disorders can be complex, and treatment often requires a personalized approach. Your healthcare provider may have determined that the benefits of using both medications outweigh the risks, especially if your symptoms indicate that your thyroid levels are not adequately controlled with Tapazole alone.

5. Consultation with Your Doctor: It is essential to maintain open communication with your healthcare provider regarding any concerns you have about your treatment regimen. If you feel uncertain about the rationale behind taking both medications, do not hesitate to ask your doctor for clarification. They can provide insights into your specific condition and the goals of your treatment plan.

In summary, while it may seem counterintuitive to take medications for both hyperthyroidism and hypothyroidism simultaneously, this approach can be necessary to achieve a balanced thyroid function. Your doctor’s decision to adjust your medications is likely based on your individual health needs and the goal of stabilizing your thyroid hormone levels. Regular follow-ups and lab tests will help ensure that your treatment remains effective and safe.

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