From Depression to Bipolar Disorder: the Transition - Psychiatry

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Regarding the transition from depression to bipolar disorder?


Hello Doctor: My father (the patient, 53 years old) suffered from depression several years ago.
After seeking treatment and taking medication, he showed improvement two years ago and subsequently stopped taking his antidepressant (Wellbutrin XL 150mg/Bupropion XL 150mg) on his own.
He has only been taking half a tablet each of sleep medication (Stilnox 10mg/Zolpidem 10mg and Rivotril 2mg/Clonazepam 2mg).
However, in the past few months, he has exhibited symptoms similar to bipolar disorder (decreased sleep, excessive talking and repetition, elevated mood, increased energy, etc.).
Since his follow-up appointment is not until next month, should he resume the previously discontinued medication, or should we observe for a while until the next appointment? Thank you!

Mr. Lai, 20~29 year old female. Ask Date: 2016/02/22

Dr. Li Zhengfeng reply Psychiatry


Hello: Bipolar disorder is characterized by alternating episodes of mania and depression.
The medications used during manic and depressive phases are different; antidepressants should not be used during manic episodes, as they may exacerbate symptoms.
It is advisable to schedule an earlier follow-up appointment.
Wishing your father a speedy recovery.

Reply Date: 2016/02/22

More Info


The transition from depression to bipolar disorder is a complex and nuanced process that can be challenging for both patients and their families to understand. In your father's case, it appears that he has a history of major depressive disorder, which he managed with medication for some time before discontinuing treatment. Recently, he has exhibited symptoms that are characteristic of bipolar disorder, such as decreased need for sleep, increased talkativeness, elevated mood, and heightened energy levels. These symptoms can be indicative of a manic or hypomanic episode, which is a hallmark of bipolar disorder.

Firstly, it is important to recognize that bipolar disorder can sometimes emerge after a period of major depressive disorder, especially if the individual has experienced multiple episodes of depression. The symptoms your father is experiencing may suggest that he is entering a manic phase, which can occur in individuals with a predisposition to bipolar disorder. It is crucial to differentiate between a simple mood elevation and a full-blown manic episode, as the latter can lead to significant impairment and risky behaviors.

Given that your father has a history of depression and is now showing signs of potential mania, it is advisable to consult with his healthcare provider as soon as possible. While waiting for the next scheduled appointment may seem reasonable, the emergence of manic symptoms can escalate quickly and may require immediate intervention. It is not uncommon for individuals who have previously been treated for depression to experience a shift in their diagnosis, especially if they have not been consistently monitored or treated.

Regarding the medications, it is essential to approach this matter with caution. Reintroducing the previously prescribed antidepressant (Wellbutrin XL) without a thorough evaluation by a psychiatrist could potentially exacerbate manic symptoms. Antidepressants can sometimes trigger manic episodes in individuals with bipolar disorder, particularly if they are not paired with a mood stabilizer or an antipsychotic. Therefore, it is crucial that your father’s treatment plan be reassessed by a mental health professional who can evaluate his current symptoms and determine the most appropriate course of action.

In the meantime, it may be beneficial for your father to maintain a mood diary, documenting his daily mood, sleep patterns, energy levels, and any significant life events. This information can provide valuable insights for his healthcare provider during the next appointment. Additionally, ensuring a supportive environment at home can help manage any potential mood swings and provide a sense of stability.

In summary, the transition from depression to bipolar disorder is not uncommon and can occur in individuals with a history of mood disorders. Given your father's recent symptoms, it is crucial to seek immediate professional advice rather than waiting for the next scheduled appointment. A mental health professional can provide a comprehensive evaluation and adjust his treatment plan accordingly, ensuring that he receives the appropriate care to manage his symptoms effectively.

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