Effective Treatments for Autoimmune-Related Itching in Seniors - Dermatology

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Regarding itching caused by autoimmune system disorders in mothers?


Hello, Doctor! My mother has been suffering from itching caused by autoimmune system dysregulation for the past few years.
Each episode is characterized by redness, swelling, and itching, affecting her limbs and body, often symmetrically.
When it gets severe, she can itch all day long, which is very uncomfortable.
She is unable to scratch, so she can only pat the affected areas, but this does not provide relief.
Previously, she visited other hospitals and was prescribed Compesolon (5mg), usually receiving a three-day supply, taking two tablets twice a day, totaling four tablets daily.
However, recently this medication has become less effective, and as soon as the three-day course is finished, the symptoms flare up again.
Once an episode starts, it is very difficult to control, causing her significant discomfort.
I would like to ask the doctor if there are more effective medications than Compesolon to treat my mother's condition, or if there are other treatment options you could recommend.
Thank you very much for your time!

Xinbei Ren, 20~29 year old female. Ask Date: 2016/02/24

Dr. Wu Yuxin reply Dermatology


Since you have already sought medical attention, you should communicate with your mother's physician, as I do not fully understand her condition.
"Itching caused by autoimmune system dysfunction" is indeed too vague.

Reply Date: 2016/02/24

More Info


When dealing with autoimmune-related itching, especially in seniors, it is crucial to approach the situation with a comprehensive understanding of the underlying condition and the available treatment options. Autoimmune disorders can manifest in various ways, including skin symptoms such as itching, redness, and swelling. In your mother's case, it seems she is experiencing significant discomfort due to her autoimmune condition, which is not adequately managed by her current medication, Compesolon (a corticosteroid).

Corticosteroids like Compesolon are often prescribed to reduce inflammation and suppress the immune response. However, they can have limitations, especially when used long-term, as they may lead to side effects and may not always provide sufficient relief. Given that your mother has been experiencing persistent symptoms even while on this medication, it may be time to consider alternative treatments or additional therapies.

1. Topical Treatments: For localized itching, topical corticosteroids can be effective. These are applied directly to the affected areas and can help reduce inflammation and itching. Additionally, non-steroidal topical treatments, such as calcineurin inhibitors (e.g., tacrolimus or pimecrolimus), can be beneficial for sensitive areas and may have fewer side effects than long-term steroid use.

2. Antihistamines: Oral antihistamines can help alleviate itching by blocking histamine receptors. First-generation antihistamines (like diphenhydramine) may cause sedation, which can be helpful at night, while second-generation antihistamines (like cetirizine or loratadine) are less sedating and can be taken during the day.

3. Immunosuppressive Agents: If corticosteroids are not effective, other immunosuppressive medications may be considered. Drugs like azathioprine or mycophenolate mofetil can help manage autoimmune conditions by suppressing the immune system more broadly. However, these medications require careful monitoring due to potential side effects.

4. Biologic Therapies: In recent years, biologic therapies have emerged as a treatment option for various autoimmune conditions. These medications target specific pathways in the immune system and can be effective in managing symptoms. Examples include agents that inhibit tumor necrosis factor (TNF) or interleukin pathways.

5. Lifestyle Modifications: Encouraging your mother to maintain a gentle skincare routine can also help. This includes using mild soaps, avoiding hot showers, and applying moisturizers regularly to keep the skin hydrated. Additionally, identifying and avoiding potential triggers (such as certain fabrics, soaps, or environmental factors) can help reduce flare-ups.

6. Consultation with Specialists: Given the complexity of autoimmune conditions, it may be beneficial to consult with a dermatologist or a rheumatologist who specializes in autoimmune diseases. They can provide a more tailored treatment plan based on your mother's specific condition and symptoms.

7. Alternative Therapies: Some patients find relief through complementary therapies such as acupuncture, meditation, or dietary changes. While these should not replace conventional treatments, they may provide additional relief and improve overall well-being.

In conclusion, while Compesolon has been a part of your mother's treatment, its ineffectiveness in controlling her symptoms suggests that a reassessment of her treatment plan is necessary. Engaging with her healthcare provider to explore alternative medications, topical treatments, and possibly referral to a specialist will be crucial in managing her autoimmune-related itching effectively. It is essential to ensure that any new treatment plan is closely monitored to manage potential side effects and assess effectiveness.

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