Monocular Diplopia: Causes and Concerns in Eye Health - Ophthalmology

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Monocular diplopia


Hello Doctor: I am experiencing sudden diplopia in my right eye, along with a decrease in vision.
My eyesight was normal after correction, but within a day or two, I remember waking up one night with a sudden headache on the right side, and after that, the next day, I started experiencing diplopia in my right eye.
I underwent OCT, MRI, visual field tests, and fundus photography, but both Hsinchu Mackay Memorial Hospital and Linkou Chang Gung Memorial Hospital's ophthalmology departments said there were no issues.
I researched unilateral diplopia online and found it to be quite challenging: 1.
Since it is unilateral diplopia, brain nerve issues have been ruled out.
2.
The MRI showed no white matter lesions, and the nerve thickness was normal, so the doctors said it is not optic neuritis.
3.
The ocular muscle CT scan also showed no inflammation, and I do not have any eyelid drooping or facial weakness, and there is no pain when moving my right eye, so it is not orbital myositis.
4.
I do not have diabetes, hypertension, or other related issues, so those have been ruled out.
5.
The only possibility I think could be myasthenia gravis, as it can cause unilateral diplopia.
However, I do not have any muscle weakness, respiratory difficulties, or swallowing issues, but I have had long-term tightness and pain in my right shoulder and neck.
I have also been taking anti-anxiety and antidepressant medications for a long time; could this be a possibility? However, with anxiety, there should be elevated acetylcholine or an excess of neurotransmitters, making it unlikely to have both anxiety and myasthenia gravis.
I have already consulted two hospitals, both of which said there were no issues.
I would like to ask you, Doctor, what other potential causes do you think there could be for unilateral diplopia?

Hsu Yu-Chen, 20~29 year old female. Ask Date: 2016/03/04

Dr. Wang Zhishun reply Ophthalmology


Hello, the causes of monocular diplopia can include refractive errors, as well as issues ranging from the eyelid to the retina.
It is better to have a physician help you identify the cause.
Additionally, myasthenia gravis can also present solely in the eyes, so it may be worthwhile to consult an ophthalmologist or a neuro-ophthalmologist for evaluation.

Reply Date: 2016/03/04

More Info


Monocular diplopia, or double vision in one eye, can be a perplexing condition that often raises concerns about underlying health issues. Given your detailed description of symptoms and the extensive evaluations you've undergone, it's important to consider several potential causes and implications for your eye health.

Firstly, monocular diplopia can arise from various factors, including refractive errors, lens opacities, or issues with the retina. Since you mentioned that you have undergone OCT (Optical Coherence Tomography), MRI, visual field tests, and other imaging studies, and that these tests returned normal results, it suggests that significant structural abnormalities in the eye or brain are less likely. However, it’s crucial to consider the possibility of subtle changes that might not be easily detectable through standard imaging.

One potential cause of your symptoms could be related to the cornea or lens. For instance, irregularities in the cornea, such as astigmatism or keratoconus, can lead to distorted vision. Additionally, cataracts or other lens opacities can also cause visual disturbances, including diplopia. Given that you have not reported any issues with the cornea or lens during your examinations, this may be less likely, but it could be worth revisiting with your eye care provider.

Another consideration is the role of muscle control and coordination. Although your MRI and muscle scans did not indicate inflammation or other issues, it’s possible that there could be a functional problem with the extraocular muscles that control eye movement. Conditions such as myasthenia gravis can lead to fluctuating muscle weakness, including the muscles responsible for eye movement, potentially causing diplopia. While you do not report significant muscle weakness or other classic symptoms of myasthenia gravis, the chronic tension and pain in your neck and shoulder could indicate a broader neuromuscular issue that warrants further exploration.

Additionally, the medications you are taking for anxiety and depression may have side effects that could contribute to visual disturbances. Some psychiatric medications can affect visual processing or cause side effects that might mimic or exacerbate existing eye conditions. It would be prudent to discuss these medications with your prescribing physician to evaluate whether they could be influencing your symptoms.

Lastly, stress and anxiety can manifest in various physical symptoms, including visual disturbances. The connection between psychological well-being and physical health is well-documented, and anxiety can sometimes lead to heightened awareness of bodily sensations, including visual anomalies. Engaging in stress-reduction techniques, such as mindfulness or cognitive-behavioral therapy, may help alleviate some of the anxiety surrounding your symptoms.

In conclusion, while your extensive evaluations have ruled out many serious conditions, it may be beneficial to continue monitoring your symptoms and maintain open communication with your healthcare providers. If your symptoms persist or worsen, consider seeking a second opinion from a specialist in neuro-ophthalmology or a comprehensive eye care center that can provide a more in-depth analysis of your condition. Additionally, addressing any underlying stress or anxiety through appropriate therapeutic measures may also contribute positively to your overall eye health and well-being.

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