Rising CEA Levels and Abnormal Blood Cells After Breast Cancer Surgery - Oncology

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Post-operative increase in CEA levels in breast cancer and the presence of abnormal cells in the blood?


Hello Dr.
Chen, I am a breast cancer patient.
After surgery in 2012, I underwent chemotherapy and have been taking Tamoxifen ever since.
To prevent and detect any signs of recurrence early, I have annual check-ups in addition to regular follow-ups.
Over the past three years, I have observed that my preoperative CEA level was 1.03, which has gradually increased to 2.2 and then 3.2.
At the same time, my white blood cell count has consistently been on the lower end.
In my most recent health check, there were "abnormal cells in the blood" - specifically, abnormal Monocytes and Reactive Lymphocytes.
However, all imaging tests have shown no issues.
When I consulted a hematologist about these findings, the doctor mentioned that these blood indices and phenomena are not significant and advised me not to worry unnecessarily.
My concern is that since there is always a possibility of recurrence, I want to be able to detect and address any issues as early as possible.
While I understand that I shouldn't be overly worried, I still see some concerning blood indices.
Should I continue with regular health checks while ignoring these abnormalities, or should I enhance my follow-up care? Do these blood indices hold any significance in preventive medicine? Thank you.

Ms. Hu, 40~49 year old female. Ask Date: 2016/03/10

Dr. Chen Yunfang reply Oncology


Hello: The reference values for CEA can vary among different hospitals, but generally, the upper limit is between 5 and 8.
Even healthy individuals will have a measurable value, which cannot be zero.
Therefore, I agree with your physician's statement that it doesn't hold much significance.
Additionally, monocytes and reactive lymphocytes are present in normal individuals as well, and they do not necessarily indicate anything specific in a clinical context; they are merely for reference.
Thank you for your understanding!

Reply Date: 2016/03/10

More Info


Understanding the implications of rising CEA levels and abnormal blood cells after breast cancer surgery is a complex issue that requires careful consideration of various factors. As a breast cancer survivor, your concerns about the potential for recurrence and the significance of your lab results are entirely valid.
Carcinoembryonic antigen (CEA) is a protein that can be found in higher levels in certain types of cancers, including breast cancer. However, it is important to note that CEA is not exclusively a cancer marker; it can also be elevated in benign conditions, such as smoking, inflammatory diseases, and certain gastrointestinal disorders. The normal range for CEA can vary by laboratory, but generally, a level below 5 ng/mL is considered normal. Your levels of 2.2 and 3.2, while elevated compared to your pre-surgery level of 1.03, are still within the range that many clinicians would consider non-alarming.
The presence of abnormal blood cells, such as elevated monocytes and reactive lymphocytes, can also be influenced by a variety of factors, including infections, inflammation, or even stress. These findings alone do not necessarily indicate a recurrence of cancer. Your hematologist's reassurance that these results may not have significant clinical implications is consistent with the understanding that lab results must be interpreted in the context of the whole patient, including symptoms, physical examination findings, and imaging studies.

Given that your imaging studies have not shown any concerning findings, it may be appropriate to continue with regular monitoring rather than jumping to conclusions based on isolated lab results. It is crucial to maintain open communication with your healthcare team. If you feel uncertain or anxious about your situation, consider discussing your concerns with your oncologist or primary care physician. They can provide a more comprehensive evaluation and may suggest additional tests or follow-up strategies tailored to your specific case.

In terms of prevention and monitoring for recurrence, it is essential to adhere to the follow-up schedule recommended by your healthcare provider. This typically includes regular physical exams, imaging studies, and blood tests. If you notice any new symptoms, such as unexplained weight loss, persistent pain, or changes in your health status, you should report these to your doctor promptly.

In summary, while rising CEA levels and abnormal blood cells can be concerning, they do not automatically indicate cancer recurrence, especially in the absence of other symptoms or abnormal imaging results. Regular follow-up and communication with your healthcare team are key components of your ongoing care. It is also beneficial to engage in a healthy lifestyle, including a balanced diet, regular exercise, and stress management techniques, which can contribute to your overall well-being and may help mitigate anxiety related to your health status. Remember, you are not alone in this journey, and there are resources and support systems available to help you navigate your concerns.

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