Polycystic Ovary Syndrome: Symptoms, Tests, and Timing - Obstetrics and Gynecology

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Hello doctor, I have had one natural miscarriage and one dilation and curettage (D&C) procedure, but I have not been pregnant at other times.
Does this indicate a possibility of polycystic ovary syndrome (PCOS)? I would like to ask what tests are needed to check for PCOS besides ultrasound, and which blood markers should be evaluated? I want to get tested, but I'm unsure on which day of my menstrual cycle I should do the tests, or if it can be done at any time.
Thank you, doctor.

sa, 30~39 year old female. Ask Date: 2016/03/16

Dr. Xu Junrui reply Obstetrics and Gynecology


Polycystic ovary syndrome (PCOS) not only makes it difficult to conceive but is also commonly associated with irregular menstruation (occurring every few months).
If you suspect you have this condition, it is advisable to consult a physician directly.
The standard diagnosis for polycystic ovaries primarily relies on ultrasound, and the timing of the examination is generally not a concern.
Of course, some physicians may also recommend further blood tests, which may vary depending on the individual physician's professional judgment.

Reply Date: 2016/03/16

More Info


Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that affects women of reproductive age. It is characterized by a combination of symptoms that can include irregular menstrual cycles, excess androgen levels (which can lead to symptoms such as acne, hirsutism, and male-pattern baldness), and polycystic ovaries as seen on ultrasound. Understanding PCOS is crucial for diagnosis and management, especially for women who may be experiencing fertility issues.

Given your history of miscarriage and the absence of successful pregnancies, it is indeed possible that you could have PCOS. The condition is known to affect ovulation, which can lead to difficulties in conceiving. Women with PCOS often experience irregular menstrual cycles, which can be a sign of anovulation (lack of ovulation).
To diagnose PCOS, healthcare providers typically rely on a combination of clinical symptoms, laboratory tests, and imaging studies. The Rotterdam criteria are commonly used for diagnosis and require the presence of at least two of the following three features:
1. Irregular or absent ovulation (which can be inferred from irregular menstrual cycles).

2. Clinical or biochemical signs of hyperandrogenism (such as elevated testosterone levels, acne, or excessive hair growth).

3. Polycystic ovaries observed via ultrasound.

In terms of laboratory tests, several hormone levels are typically evaluated:
- Luteinizing Hormone (LH): Often elevated in women with PCOS.

- Follicle-Stimulating Hormone (FSH): Usually normal or low in PCOS.

- Testosterone: Elevated levels can indicate hyperandrogenism.

- Estradiol (E2): This can help assess ovarian function.

- Anti-Müllerian Hormone (AMH): Elevated levels can suggest polycystic ovaries.

Regarding the timing of blood tests, it is generally recommended to have certain hormone levels checked at specific times during your menstrual cycle. For example, FSH and estradiol are often measured on day 2 or 3 of the menstrual cycle, as this is when these hormones are at baseline levels. However, tests for LH and testosterone can be done at any time, as they do not fluctuate as dramatically throughout the cycle.

If you have irregular cycles, it may be challenging to determine the exact timing for testing. In such cases, your healthcare provider may suggest performing tests based on your symptoms or may recommend a specific time frame that works best for you.
In summary, if you suspect you have PCOS, it is essential to consult with a healthcare provider who can guide you through the diagnostic process. They will likely recommend a combination of ultrasound and blood tests to evaluate your hormone levels and assess your ovarian health. Additionally, lifestyle modifications such as maintaining a healthy weight, regular exercise, and a balanced diet can significantly help manage symptoms of PCOS. If you are considering pregnancy, discussing fertility options with your healthcare provider is also advisable, as they can provide tailored recommendations based on your specific situation.

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