Antidepressants: Managing Symptoms and Side Effects - Psychiatry

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Medications for Depression


Hello, I recently visited a psychiatrist and was diagnosed with moderate depression.
The doctor prescribed me medication, and although I've noticed that my mood has stabilized significantly over the past week and my crying frequency has decreased, I still find myself lying in bed all day without the motivation to do anything.
I just want to sleep or feel completely indifferent, unable to manage household chores or even muster the energy to go outside.
I'm feeling very scared and wondering if the medication is ineffective or if the side effects are too severe...

Niming, 20~29 year old female. Ask Date: 2016/03/29

Dr. Li Zhengfeng reply Psychiatry


Hello: Antidepressant medications typically take more than two weeks to show significant effects, so please be patient.
Wishing you a speedy recovery.

Reply Date: 2016/03/29

More Info


It's great that you've reached out for help regarding your mental health. Understanding how antidepressants work and managing their symptoms and side effects is crucial for anyone undergoing treatment for depression.

Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) like Zoloft (Sertraline), are commonly prescribed for conditions such as major depressive disorder, anxiety disorders, and obsessive-compulsive disorder. They work by increasing the levels of serotonin in the brain, which can help improve mood and emotional stability. However, it’s important to note that while many people experience significant improvements, others may have a slower response to medication or may not respond as well.

From your description, it sounds like you are experiencing some common effects of starting an antidepressant. Initially, many patients notice a reduction in emotional distress, such as crying spells, but they may still feel lethargic or unmotivated. This can be frustrating, especially when you expect the medication to resolve all symptoms quickly. It’s essential to understand that antidepressants often take several weeks to reach their full effect. In many cases, it can take anywhere from 4 to 6 weeks to feel the full benefits of the medication.

Your feelings of lethargy and lack of motivation, despite some emotional improvement, can be attributed to several factors. First, the medication may still be adjusting in your system. Second, depression itself can manifest as a lack of energy and motivation, which can persist even when other symptoms improve. Third, some individuals may experience side effects such as fatigue or sedation, especially when starting a new medication.

Here are some strategies to consider while you navigate this period:
1. Communicate with Your Doctor: It's crucial to keep an open line of communication with your healthcare provider. If you feel that the medication is not working as expected or if side effects are overwhelming, discuss these concerns with your doctor. They may adjust your dosage or consider switching you to a different medication.

2. Establish a Routine: Even if you don’t feel like it, try to establish a daily routine. This can include small tasks like getting out of bed at a certain time, taking a shower, or preparing meals. Setting small, achievable goals can help create a sense of accomplishment.

3. Engage in Light Activity: Physical activity can be beneficial for mental health. Even a short walk or gentle stretching can help improve your mood and energy levels. Exercise releases endorphins, which can enhance feelings of well-being.

4. Social Support: Reach out to friends or family members. Social interaction can be incredibly beneficial, even if it’s just a phone call or a brief visit. Sharing your feelings with someone you trust can help alleviate some of the burden.

5. Mindfulness and Relaxation Techniques: Practices such as mindfulness, meditation, or yoga can help manage anxiety and improve your mood. These techniques can help you stay present and reduce feelings of being overwhelmed.

6. Monitor Your Symptoms: Keep a journal of your feelings, energy levels, and any side effects you experience. This can help you and your doctor identify patterns and make informed decisions about your treatment.

7. Be Patient: Recovery from depression is often not linear. There will be good days and bad days. It’s important to be patient with yourself and recognize that healing takes time.

If after a reasonable period you still feel stuck or if your symptoms worsen, it may be time to revisit your treatment plan with your healthcare provider. They may suggest therapy in conjunction with medication, which can provide additional support and coping strategies.

In summary, while it’s understandable to feel concerned about your current state, remember that antidepressants can take time to work effectively. Stay engaged with your treatment team, and don’t hesitate to seek additional support when needed. You are not alone in this journey, and there are many resources available to help you navigate through your depression.

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