Liver Health: Do You Need Fibrosis Testing for Hepatitis B? - Gastroenterology and Hepatology

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Is it cirrhosis?


Hello, doctor.
I recently had an abdominal ultrasound that showed my liver is enlarged.
Subsequent blood tests indicated that my Hepatitis B surface antigen is negative, but my surface antibody and core antibody are positive.
I have never been vaccinated, so it seems I have developed these antibodies on my own.
I would like to undergo a liver elastography test, but my doctor said it is unnecessary.
Also, do I need to take antiviral medication for treatment? I read online that even if the Hepatitis B surface antigen is negative, antiviral medication should still be taken because the virus may still be present in the liver.
Is this true? My spleen is slightly enlarged, and I have been feeling fatigued lately.
I won't return for a follow-up until next month, and I am worried that I may have developed liver cirrhosis.
Thank you.

Ms. Li, 40~49 year old female. Ask Date: 2016/03/31

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: A negative hepatitis B surface antigen means that there is no hepatitis B virus carrier status, and there is no need for any medication.
There is a significant difference between liver fibrosis and cirrhosis, so there is no need to be overly concerned about cirrhosis.
As for splenomegaly, you can consult a hematologist to determine the cause.
Changhua Hospital cares about your health.
Dr.
Tsai An-shun

Reply Date: 2016/03/31

More Info


When it comes to managing Hepatitis B and understanding liver health, it is crucial to interpret test results and symptoms accurately. Based on your situation, you have undergone an abdominal ultrasound that indicated a rough liver texture, and your blood tests show that you are HBsAg negative, Anti-HBs positive, and Anti-HBc positive. This combination of results suggests that you have had a past infection with Hepatitis B, but your body has developed antibodies against the virus, indicating that you are likely immune.

However, the concern about liver fibrosis and the need for further testing is valid. Fibrosis testing, such as liver elastography (FibroScan), is often recommended for individuals with a history of Hepatitis B, especially if there are signs of liver damage or if the patient is at risk for liver disease. The rough texture of your liver observed on ultrasound could indicate some degree of fibrosis or liver damage, which is why you might want to pursue this testing despite your doctor's opinion that it may not be necessary.

Regarding antiviral treatment, the general guideline is that if you are HBsAg negative and have developed Anti-HBs, you are typically not considered to be actively infected with Hepatitis B. However, the presence of Anti-HBc indicates that you have been exposed to the virus in the past. The concern arises if there is any possibility of reactivation of the virus, especially if there are risk factors present, such as a compromised immune system or other liver conditions.

It is important to note that while some articles may suggest that anyone with a history of Hepatitis B should be on antiviral medication, this is not universally applicable. The decision to start antiviral therapy should be based on a comprehensive evaluation of your liver function tests, the degree of fibrosis (if assessed), and any symptoms you may be experiencing. If your liver enzymes (ALT and AST) are normal and there is no evidence of significant fibrosis or cirrhosis, your doctor may determine that antiviral therapy is not necessary at this time.

Your enlarged spleen and fatigue are concerning symptoms that warrant further investigation. An enlarged spleen can be associated with various conditions, including liver disease, and it is essential to discuss these symptoms with your healthcare provider. They may recommend additional tests, such as a complete blood count (CBC) or further imaging studies, to assess the underlying cause of your symptoms.

In summary, while your current test results suggest that you are not actively infected with Hepatitis B, the history of the virus and the rough texture of your liver warrant further evaluation. Fibrosis testing could provide valuable information about the health of your liver, and it is essential to have an open dialogue with your healthcare provider about your symptoms and concerns. If you feel that your current doctor is not addressing your worries adequately, seeking a second opinion from a hepatologist or a specialist in liver diseases may be beneficial. Your health and peace of mind are paramount, and it is essential to ensure that you receive the appropriate care and monitoring for your liver health.

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