Effective Oral Treatments for Toenail Fungus with Hepatitis B - Dermatology

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Treatment for nail fungus?


Dear Doctor: I have been troubled by onychomycosis for a long time and would like to treat it with oral medication.
My liver function test results from last month showed GOT at 20 and GPT at 25.
Is it safe to proceed with treatment? Thank you.
P.S.
I am a carrier of hepatitis B, but my test results are normal.

iwen, 30~39 year old female. Ask Date: 2016/04/09

Dr. Li Yufen reply Dermatology


Hello: Regarding the treatment of onychomycosis (fungal nail infection), you can refer to the articles on the Dermatology Expert Health Network at the following links: http://www.drskincare.com.tw/Qa/Detail.aspx?ID=27 http://www.drskincare.com.tw/Qa/Detail.aspx?ID=110 Thank you!

Reply Date: 2016/04/09

More Info


When it comes to treating toenail fungus (onychomycosis) in patients who are carriers of Hepatitis B, there are several important considerations to keep in mind. First and foremost, it is essential to understand that while oral antifungal medications can be effective for treating toenail fungus, their use in patients with liver conditions, such as Hepatitis B, requires careful evaluation.

Oral antifungal medications, such as terbinafine (Lamisil) and itraconazole (Sporanox), are commonly prescribed for toenail fungus. These medications work by inhibiting the growth of the fungus, ultimately leading to the clearing of the infection. However, they can also have potential side effects, particularly on liver function. This is particularly relevant for individuals who are Hepatitis B carriers, even if their liver function tests (like GOT and GPT) are within normal ranges.

In your case, with GOT at 20 and GPT at 25, your liver function appears to be normal, which is a positive sign. However, it is crucial to have a thorough discussion with your healthcare provider before starting any oral antifungal treatment. Your doctor may recommend baseline liver function tests and possibly monitor your liver enzymes periodically during the course of treatment to ensure that there are no adverse effects on your liver.

In addition to the potential liver toxicity of oral antifungals, it is also important to consider the duration of treatment. Toenail fungus can be notoriously difficult to eradicate, often requiring several months of consistent treatment. This means that if you start an oral antifungal, you will need to commit to the treatment plan and adhere to follow-up appointments to monitor your liver health.

Moreover, if you have been experiencing toenail fungus for an extended period, as you mentioned, it may be beneficial to explore other treatment options in conjunction with oral antifungals. Topical antifungal treatments, while often less effective for severe cases, can be used alongside oral medications to enhance treatment efficacy. Additionally, maintaining good foot hygiene and addressing any underlying conditions, such as athlete's foot (tinea pedis), can help improve treatment outcomes.

Lastly, it is essential to keep in mind that while oral antifungal medications can be effective, they do not guarantee a cure. Some patients may experience recurrence of the infection, and in such cases, further evaluation and possibly alternative treatment strategies may be necessary.

In summary, while you may be a candidate for oral antifungal treatment for your toenail fungus given your normal liver function tests, it is crucial to consult with your healthcare provider. They will assess your overall health, monitor your liver function, and determine the most appropriate treatment plan tailored to your specific situation. Regular follow-up and communication with your healthcare team will be key to successfully managing both your toenail fungus and your Hepatitis B condition.

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Hello: Regarding the issue of onychomycosis (fungal nail infection), you can refer to Dr. Hsiao Yu-Ping's introduction at http://yupingblog.pixnet.net/blog/post/10035694-灰指甲的快速診斷法 and the article on the Dermatology Expert Health Network at http://www.drskincare.com.tw/Qa/Ind...

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