Can Oral Antifungal Medications Cure Toenail Fungus in Hepatitis B Carriers? - Dermatology

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Onychomycosis and Hepatitis B carrier status?


I am a carrier of hepatitis B, and my liver enzymes are normal, but I have not undergone an ultrasound examination.
I have had toenail fungus on my right big toe for 8 years, and after using Lamisil (terbinafine) for 3 bottles, the results have been unsatisfactory, with the condition worsening.
Two-thirds of the nail is yellow-brown and thickened, and I also have athlete's foot.
Can I take oral antifungal medication? Is it curable? The toenail fungus has been a long-standing issue for me.
Thank you.

Xiao Mei, 30~39 year old female. Ask Date: 2015/09/14

Dr. Li Yufen reply Dermatology


Hello: Regarding the issue of onychomycosis (fungal nail infection), you can refer to Dr.
Hsiao Yu-Ping's introduction at http://yupingblog.pixnet.net/blog/post/10035694-灰指甲的快速診斷法 and the article on the Dermatology Expert Health Network at http://www.drskincare.com.tw/Qa/Index.aspx?CID=12.
Regardless of whether one has onychomycosis, it is recommended that hepatitis B carriers undergo regular blood tests and liver ultrasounds.
Thank you!

Reply Date: 2015/09/14

More Info


Toenail fungus, medically known as onychomycosis, can be a persistent and frustrating condition, especially for individuals with underlying health issues such as hepatitis B. As a hepatitis B carrier, it is essential to approach treatment options with caution, particularly when considering oral antifungal medications.

Oral antifungal medications, such as terbinafine (Lamisil) and itraconazole (Sporanox), are often prescribed for severe cases of toenail fungus due to their effectiveness in penetrating the nail bed and eradicating the fungal infection. However, these medications can have implications for liver health, particularly in individuals with pre-existing liver conditions like hepatitis B.

In your case, since you are a hepatitis B carrier with normal liver function tests, the use of oral antifungal medications may still be an option, but it requires careful consideration and monitoring. Here are several important points to consider:
1. Liver Function Monitoring: Even though your liver function tests are currently normal, it is crucial to have regular monitoring of your liver enzymes (ALT, AST) and overall liver function before and during the treatment with oral antifungals. This is to ensure that the medications do not exacerbate any underlying liver issues.

2. Consultation with a Specialist: It is advisable to consult with a healthcare provider, preferably a hepatologist or a dermatologist experienced in treating fungal infections in patients with liver disease. They can provide personalized recommendations based on your health status and the severity of your toenail fungus.

3. Potential Alternatives: If oral antifungal medications pose too much risk, there are alternative treatments available. Topical antifungal treatments, although often less effective for severe cases, can be used in conjunction with other therapies. Additionally, laser therapy has emerged as a treatment option for toenail fungus, though its efficacy can vary.

4. Duration of Treatment: Treatment for toenail fungus typically requires several months, as nails grow slowly. It is essential to adhere to the prescribed treatment regimen and maintain follow-up appointments to assess the effectiveness of the treatment.

5. Lifestyle and Home Remedies: In addition to medical treatments, maintaining good foot hygiene, keeping your feet dry, and using antifungal powders or sprays can help manage the condition. Avoiding tight footwear and ensuring proper ventilation for your feet can also reduce fungal growth.

6. Understanding the Condition: It is important to recognize that toenail fungus can be a chronic condition, and while treatment can be effective, it may take time to see results. Patience and adherence to treatment are key.

In conclusion, while oral antifungal medications can potentially cure toenail fungus, their use in hepatitis B carriers must be approached with caution. Regular monitoring of liver function, consultation with healthcare professionals, and consideration of alternative treatments are essential steps in managing your toenail fungus effectively and safely. If you decide to pursue oral antifungal therapy, ensure that you are closely monitored throughout the treatment process to safeguard your liver health.

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Hello: Regarding the treatment of onychomycosis (fungal nail infection), you can refer to the articles on the Dermatology Expert Health Network at the following links: http://www.drskincare.com.tw/Qa/Detail.aspx?ID=27 http://www.drskincare.com.tw/Qa/Detail.aspx?ID=110 Thank you!

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