HPV Types 44 and 51: A Guide for Women's Health - Obstetrics and Gynecology

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Human Papillomavirus (HPV) types 44 and 51 infection?


Hello! I have been undergoing Pap smear tests annually, and all my reports have been normal.
The report from 2015 indicated normal results but showed signs of inflammation.
(2015 report details: Quality of specimen: Satisfactory.
Results: NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY.
Reactive changes: Inflammation, repair, radiation, and others.) On March 28, 2016, I underwent HPV testing at Chang Gung Memorial Hospital in Taipei, and the report on April 6 detected HPV types 44 and 51.
The doctor initially intended to perform a Pap smear on the same day, but during the pelvic examination, white discharge was observed, so I was prescribed a 7-day treatment for the discharge.
I returned for a follow-up on April 20 to have the Pap smear done.
Should I follow the doctor's instructions at Chang Gung to treat the discharge first and then proceed with the Pap smear? Additionally, can a diagnosis of CIN (Cervical Intraepithelial Neoplasia) only be made after completing the Pap smear? Thank you!

Taiyang, 40~49 year old female. Ask Date: 2016/04/13

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please follow the doctor's instructions.
A positive HPV test generally indicates a high-risk group, and it is important to have regular Pap smears.
Only a Pap smear can determine if there is CIN (cervical intraepithelial neoplasia).
Wishing you good health.

Reply Date: 2016/04/13

More Info


Understanding HPV Types 44 and 51 is crucial for women's health, especially considering the implications of HPV infections on cervical health. Human Papillomavirus (HPV) is a group of more than 200 related viruses, of which some are classified as high-risk types due to their association with cervical cancer and other anogenital cancers. Types 44 and 51 are considered high-risk HPV types, and their presence can be concerning, especially in the context of abnormal cervical screening results.

From your previous screenings, it appears that you have been diligent about your health, as indicated by your annual Pap smear tests, which have consistently returned normal results. The report from 2016 indicates that while you tested positive for HPV types 44 and 51, your Pap smear did not show any intraepithelial lesions or malignancy, which is reassuring. The presence of inflammation noted in your report could be due to various factors, including infections, hormonal changes, or irritation, and does not necessarily indicate a precancerous condition.

Regarding your treatment plan, it is indeed appropriate to follow your doctor’s advice to treat the white discharge before undergoing another Pap smear. The presence of an infection or inflammation can affect the accuracy of the Pap test results, potentially leading to false positives or negatives. By addressing the white discharge first, you ensure that the subsequent Pap smear will provide a clearer picture of your cervical health.

After completing the treatment for the white discharge, a follow-up Pap smear is essential. This test will help determine if there are any cervical changes, such as Cervical Intraepithelial Neoplasia (CIN), which is a precursor to cervical cancer. CIN is classified into three grades: CIN 1 (mild dysplasia), CIN 2 (moderate dysplasia), and CIN 3 (severe dysplasia). The results of the Pap smear, in conjunction with HPV testing, will guide your healthcare provider in determining the next steps.

If your follow-up Pap smear shows any abnormalities, further diagnostic procedures, such as a colposcopy and biopsy, may be recommended to assess the cervical tissue more closely. It is important to remember that many HPV infections, especially in younger women, can resolve on their own without treatment. However, regular monitoring is crucial, particularly with high-risk HPV types.

In terms of vaccination, if you have not yet received the HPV vaccine, it may still be beneficial, even in your 30s. The vaccine can protect against the most common high-risk HPV types and can be administered up to age 45 in some cases. Discussing this option with your healthcare provider can help you make an informed decision based on your health history and risk factors.

In summary, continue to follow your healthcare provider's recommendations, treat any infections, and ensure regular screenings. Understanding your HPV status and maintaining open communication with your doctor will empower you to take charge of your cervical health. Regular monitoring and preventive measures, including vaccination, can significantly reduce the risk of developing cervical cancer associated with high-risk HPV types.

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