Managing Steroid Use for Chronic Urticaria: A Patient's Guide - Dermatology

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Steroid use


Hello, Doctor.
Recently, my urticaria has flared up again.
The doctor prescribed multiple antihistamines, but they haven't been effective.
After that, I received an injection of 40 mg of methylprednisolone and was prescribed two tablets of Dexamethasone to take twice a day.
On the first day after the injection, my condition improved significantly, but on the second day, the rash suddenly worsened.
I went to the emergency room, where the doctor advised me to stop taking the corticosteroids and to return to see my outpatient doctor the next day.
The doctor mentioned that it was due to insufficient dosage.
Today, I received another injection of methylprednisolone, but I wasn't informed about how to adjust my medication.
Since I will be visiting a large hospital for an outpatient appointment on Saturday, I would like to ask how I should take the corticosteroids in the meantime, specifically how many tablets I should take to maintain a better condition.
I currently weigh 68 kg.
Thank you.

Mr. Chen, 20~29 year old female. Ask Date: 2016/04/21

Dr. Wu Yuxin reply Dermatology


The method of medication and dosage varies depending on body weight and symptoms; you should consult your physician.

Reply Date: 2016/04/21

More Info


Managing chronic urticaria can be quite challenging, especially when steroid medications are involved. It’s important to approach this situation with caution and a clear understanding of how to use these medications effectively while minimizing potential side effects.

First, let’s discuss the role of corticosteroids in treating chronic urticaria. Corticosteroids, such as methylprednisolone (the medication you received), are often prescribed to reduce inflammation and suppress the immune response that contributes to the hives. While they can be effective in providing rapid relief, they are typically not the first-line treatment for chronic urticaria due to their side effects, especially with long-term use. Antihistamines are usually the preferred initial treatment, and higher doses may be required for some patients to achieve adequate control.

In your case, it seems that the antihistamines alone were not effective, leading your physician to prescribe corticosteroids. The initial improvement you experienced after the injection is not uncommon, but the subsequent flare-up suggests that the underlying condition may not have been fully controlled. This can happen if the dose of steroids is insufficient or if there are other triggers at play.

Regarding your question about how to manage steroid use until your appointment at the larger hospital, it’s crucial to follow your doctor’s advice closely. Since you mentioned that the emergency physician advised you to stop taking steroids, it’s important to clarify whether this was a temporary measure or a permanent recommendation. If your doctor has not provided specific instructions on how to taper or adjust your steroid dosage, here are some general guidelines:
1. Tapering Off: If you have been on steroids for a short period (a few days to a week), you may not need to taper off. However, if you have been on them longer, it’s generally advisable to taper the dose gradually rather than stopping abruptly to avoid withdrawal symptoms and potential flare-ups of urticaria.

2. Dosage: The specific dosage of methylprednisolone can vary widely based on individual circumstances. A common approach is to start with a higher dose (e.g., 20-40 mg daily) and then gradually reduce it. However, since you are experiencing a flare-up, your physician may recommend maintaining a higher dose temporarily until your symptoms stabilize.

3. Monitoring Symptoms: Keep a close eye on your symptoms. If you notice that your urticaria worsens significantly after reducing the steroid dose, it may indicate that you need to maintain a higher dose for a longer period or explore alternative treatments.

4. Consulting Your Physician: Since you have an upcoming appointment at a larger hospital, it’s essential to discuss your current symptoms, the effectiveness of the treatment, and any concerns you have about steroid use with your healthcare provider. They may suggest alternative therapies, such as immunosuppressants or biologics, if your urticaria is refractory to standard treatments.

5. Lifestyle and Trigger Management: In addition to medication, consider lifestyle modifications that may help manage your urticaria. This includes identifying and avoiding potential triggers (such as certain foods, medications, or environmental factors), maintaining a cool environment, and managing stress, which can exacerbate symptoms.

In summary, while corticosteroids can provide relief for chronic urticaria, they should be used judiciously and under medical supervision. It’s crucial to communicate openly with your healthcare providers about your symptoms and treatment plan. If you have any doubts or experience worsening symptoms, don’t hesitate to seek medical advice before your scheduled appointment. Your health and well-being are the top priority, and a tailored approach to your treatment will yield the best outcomes.

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