Do Herbal Supplements Affect the Efficacy of Birth Control Pills? - Pharmacology

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Emergency contraceptive pill


Hello, I have been taking the oral contraceptive pill (Alesse) for nearly six months, and I am considering taking a dietary supplement, Kobayashi Pharmaceutical's "Mother's Life - Blue Bottle." The ingredients I found online include Angelica sinensis, Ligusticum chuanxiong, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Alisma orientale, Cinnamomum cassia, Paeonia suffruticosa, Rheum palmatum, Prunus persica, ginseng, and a complex of vitamins, along with a digestive enzyme blend and B vitamins.
Here is the link to the ingredients: http://www.momoshop.com.tw/goods/GoodsDetail.jsp?mdiv=ghostShopCart&i_code=3447089.
I would like to know if these two products could affect the effectiveness of the contraceptive.
Thank you for your attention, doctor.

Qiao, 20~29 year old female. Ask Date: 2016/04/22

Dr. Hou Fangmin reply Pharmacology


Hello, Miss Qiao:
1.
The oral contraceptive Diane contains two hormones: cyproterone acetate 2mg (a progestin with anti-androgenic properties) and ethinylestradiol 35μg (an estrogen), which are similar to the natural hormones secreted by the female ovaries, making it suitable for use as an oral contraceptive for women.
Additionally, the anti-androgen component in Diane helps reduce acne by decreasing excess oil production in the skin and can also alleviate symptoms of hirsutism.
2.
Literature indicates that certain Western medications (such as phenytoin, barbiturates, primidone, carbamazepine, and rifampicin) can induce microsomal enzymes that accelerate the clearance of sex hormones, leading to more interactions when using these medications.
3.
Regarding traditional Chinese medicine, it has been noted that herbs containing Angelica sinensis may have a synergistic effect with estrogen, necessitating dosage adjustments.
Additionally, the herb rhubarb contains tannins, which can precipitate with vitamin thiamine, reducing the efficacy of oral Western medications.
It is advisable to space the intake of these medications by at least 2 hours to minimize interactions.
I am providing you with a website for checking drug interactions between Western and traditional Chinese medicines (http://dhi.cmu.edu.tw/query/).
If you have any questions about medications in the future, you can refer to this resource.
Wishing you peace and happiness.

Reply Date: 2016/04/22

More Info


The interaction between herbal supplements and birth control pills is a topic of significant interest and concern for many women. When considering the use of herbal supplements while on birth control, it is essential to understand how certain herbs can potentially affect the efficacy of hormonal contraceptives.

Firstly, it is important to note that some herbal supplements can indeed interfere with the effectiveness of birth control pills. One of the most well-known examples is St. John's Wort (Hypericum perforatum), which is commonly used for its antidepressant properties. St. John's Wort can induce liver enzymes that metabolize hormones, potentially leading to reduced levels of contraceptive hormones in the bloodstream. This can increase the risk of unintended pregnancy.

In your case, you mentioned considering a supplement that contains various herbal ingredients, including Dong Quai (Angelica sinensis), Chuanxiong (Ligusticum chuanxiong), Peony (Paeonia lactiflora), and others. While these herbs are often used in traditional medicine for various purposes, there is limited scientific evidence regarding their specific interactions with hormonal contraceptives.
For instance, Dong Quai is traditionally used for menstrual and reproductive health, but its effects on hormonal balance and birth control efficacy are not well-studied. Similarly, while some of the other ingredients may have health benefits, their impact on the metabolism of contraceptive hormones is not clearly established.
Moreover, the presence of certain vitamins and enzymes in your supplement could also play a role in how your body processes medications. For example, B vitamins are essential for various metabolic processes, but they do not have a known direct effect on the efficacy of birth control pills.

Given the complexity of herbal supplements and their potential interactions with medications, it is crucial to approach this situation with caution. Here are some recommendations:
1. Consult Your Healthcare Provider: Before starting any new supplement, especially while on birth control pills, it is essential to discuss it with your healthcare provider. They can provide personalized advice based on your health history and the specific supplements you are considering.

2. Monitor for Side Effects: If you decide to take the herbal supplement, keep an eye out for any unusual side effects or changes in your menstrual cycle, as these could indicate an interaction.

3. Consider Alternative Options: If you are concerned about the potential interactions, you might want to explore other ways to support your health that do not involve herbal supplements, such as dietary changes or lifestyle modifications.

4. Stay Informed: Continue to educate yourself about the ingredients in any supplements you take. Understanding their effects and potential interactions with medications is crucial for your health.

In conclusion, while not all herbal supplements will affect the efficacy of birth control pills, some can. Given the ingredients in the supplement you are considering, it is best to consult with your healthcare provider to ensure that you are making safe choices for your reproductive health. Always prioritize open communication with your healthcare team to navigate any concerns regarding medications and supplements effectively.

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