Can Enbrel Injections Help with Severe Iritis Flare-Ups? - Ophthalmology

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Enbrel (etanercept) is a biologic medication primarily used to treat autoimmune conditions such as rheumatoid arthritis, ankylosing spondylitis, and psoriasis. It works by inhibiting tumor necrosis factor (TNF), a substance in the body that leads to inflammation in autoimmune diseases. Given your history of ankylosing spondylitis and the current flare-up of severe iritis, it is understandable to consider whether Enbrel could be beneficial in managing your symptoms.

Iritis, or inflammation of the iris, can be associated with systemic inflammatory conditions, including ankylosing spondylitis. The management of iritis typically involves corticosteroids to reduce inflammation and prevent complications such as adhesions or glaucoma. However, in cases where iritis is recurrent or associated with an underlying autoimmune condition, the use of systemic treatments like Enbrel may be considered.

The use of Enbrel in the context of severe iritis is not a standard treatment protocol, but it may be beneficial if the iritis is part of the broader inflammatory process associated with ankylosing spondylitis. By controlling the underlying inflammation, Enbrel may help reduce the frequency and severity of iritis flare-ups. However, it is crucial to note that Enbrel is not specifically indicated for the treatment of iritis, and its use should be carefully evaluated by your healthcare provider.

Before starting Enbrel, it is essential to discuss the following with your physician:
1. Current Medications: Ensure that there are no contraindications with your current medications, especially if you are already on corticosteroids or other immunosuppressive therapies.

2. Infection Risk: Enbrel can increase the risk of infections due to its immunosuppressive effects. Your doctor will assess your overall health and any potential risks before initiating treatment.

3. Monitoring: If you start Enbrel, your doctor will likely want to monitor you closely for any side effects or complications, particularly since you are experiencing a severe flare-up of iritis.

4. Alternative Treatments: Discuss other treatment options for managing your iritis, including corticosteroid eye drops or other immunomodulatory therapies that may be more directly indicated for ocular inflammation.

5. Consultation with an Ophthalmologist: It may be beneficial to consult with an ophthalmologist who specializes in uveitis or iritis to ensure that you receive comprehensive care for your eye condition.

In summary, while Enbrel may help manage the underlying inflammatory process associated with ankylosing spondylitis, its use for severe iritis should be carefully considered and discussed with your healthcare provider. They will be able to provide personalized advice based on your specific medical history and current condition. Always prioritize communication with your healthcare team to ensure the best possible outcomes for both your iritis and ankylosing spondylitis.