Antibiotic Recommendations for Mitral Valve Prolapse Surgery - Cardiology

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Mitral valve prolapse - Antibiotic prophylaxis before surgery?


Hello, Director.
Thank you for your response! However, the doctor who will perform my surgery said he is unsure and asked me to prepare the antibiotics myself.
Could you please let me know what type of antibiotics I should take and where I can purchase them? Thank you!

Niming, 30~39 year old female. Ask Date: 2016/05/05

Dr. He Dongjin reply Cardiology


Hello, if a pharmacist at a regular pharmacy is willing to dispense medication without a prescription, they may provide amoxicillin, ampicillin, or oral first-generation cephalosporins such as cephalexin.
Thank you for your concern from Changhua Hospital.

Reply Date: 2016/05/05

More Info


When it comes to antibiotic prophylaxis for patients with mitral valve prolapse (MVP) undergoing surgery, the recommendations can vary based on individual risk factors and the type of procedure being performed. In general, the American Heart Association (AHA) guidelines suggest that antibiotic prophylaxis is necessary for certain high-risk patients undergoing specific dental or surgical procedures that may introduce bacteria into the bloodstream, potentially leading to infective endocarditis.

For patients with MVP, especially those with significant regurgitation or a history of infective endocarditis, prophylactic antibiotics may be recommended prior to procedures that have a higher risk of bacteremia, such as dental extractions or invasive surgeries. However, for routine surgical procedures, such as the removal of a cyst or other minor surgeries, the need for prophylactic antibiotics is less clear and often not required.

In your case, if your doctor has advised you to prepare your own antibiotics, the commonly recommended antibiotics for prophylaxis include:
1. Amoxicillin: This is the first-line antibiotic for most patients. The typical dosage is 2 grams taken orally 30 to 60 minutes before the procedure.

2. Ampicillin: If you are unable to take oral medications, ampicillin can be given intravenously (IV) at a dose of 2 grams.

3. Cephalexin: For those allergic to penicillin, cephalexin (2 grams orally) can be an alternative.

4. Clindamycin: Another alternative for penicillin-allergic patients is clindamycin, which can be given at a dose of 600 mg orally.

You can typically purchase these antibiotics at a pharmacy, but it is essential to have a prescription from a healthcare provider. It is crucial to consult with your surgeon or a healthcare professional to ensure that you are taking the appropriate antibiotic for your specific situation and to confirm the dosage and timing.

Regarding your concern about the risk of infection from the cyst removal and the potential for infective endocarditis, it is important to note that while any surgical procedure carries some risk of infection, the likelihood of developing infective endocarditis from a minor procedure like cyst removal is generally low, especially if proper sterile techniques are followed. Symptoms of infective endocarditis can include persistent fever, chills, fatigue, and new or worsening heart murmurs. If you experience any of these symptoms, especially after your procedure, it is crucial to contact your healthcare provider immediately.

In summary, while antibiotic prophylaxis is important for certain high-risk patients, the necessity and choice of antibiotics depend on individual circumstances. Always consult with your healthcare provider for personalized recommendations and to ensure you are adequately protected before any surgical procedure.

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