Benign Lymphoid Hyperplasia: When to Seek Further Evaluation - Otolaryngology

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Lymphoproliferation


Hello Doctor: Four months ago, I noticed a lymph node approximately 1.5 cm in size at the 2A position on both sides of my neck.
A fine needle aspiration at National Taiwan University Hospital resulted in a diagnosis of benign lymphoid hyperplasia.
However, it has been over four months since I discovered them, and these two lymph nodes have not decreased in size and feel somewhat firm.
In fact, I also have one lymph node about 1 cm in size on each side of my jaw, which I have noticed for about 10 years.
I would like to ask: 1.
Is it normal for lymph nodes with a fine needle aspiration result indicating benign lymphoid hyperplasia to remain firm and not decrease in size? 2.
Regarding the two lymph nodes on my jaw that have remained firm for 10 years, could this be due to recurrent inflammation and calcification? 3.
Some individuals have naturally enlarged lymph nodes; if this is the case, would the aspiration results also indicate lymphoid hyperplasia? 4.
Since my larger lymph nodes are symmetrically located on both sides of my neck, and although they have not decreased in size, they have not significantly enlarged either, is it sufficient to continue monitoring them?

Xiao Guan, 20~29 year old female. Ask Date: 2016/05/31

Dr. Zheng Jueyi reply Otolaryngology


Hello: If the lymphadenopathy shows normal results upon biopsy and has not changed significantly over the years, it is recommended to continue with regular monitoring.
Wishing you peace and good health.
Sincerely, Dr.
Jue-Yi Cheng, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2016/05/31

More Info


When it comes to lymph nodes, particularly in the context of benign lymphoid hyperplasia, it is essential to understand the nature of lymph nodes and the implications of their characteristics. Based on your situation, you have raised several important questions regarding the persistence and characteristics of your lymph nodes, particularly those that have been identified as benign lymphoid hyperplasia through fine needle aspiration (FNA).

1. Persistence and Hardness of Lymph Nodes: It is not uncommon for lymph nodes that have been classified as benign to remain palpable and even hard. Lymph nodes can become reactive due to various stimuli, such as infections or inflammation, and may not return to their original size even after the inciting cause has resolved. The hardness of a lymph node can be attributed to fibrosis or scarring that occurs after inflammation. Therefore, while it is normal for benign lymph nodes to remain palpable and firm, any significant changes in size, shape, or consistency should be monitored closely.

2. Long-standing Lymph Nodes: The lymph nodes you mentioned under your jaw that have persisted for about ten years could indeed be a result of chronic inflammation or repeated infections, leading to a process known as calcification or fibrosis. This can cause the lymph nodes to become hard and non-tender. Chronic lymphadenopathy can occur in some individuals without any malignant transformation, but it is crucial to keep an eye on them, especially if there are any changes.

3. Congenital Lymphadenopathy: Some individuals may have naturally larger lymph nodes due to genetic factors or congenital conditions. In such cases, FNA results may still indicate benign lymphoid hyperplasia, as the lymph nodes are functioning normally despite their size. If the lymph nodes are stable and asymptomatic, they may not require any intervention.

4. Monitoring and Observation: Given that your larger lymph nodes are symmetrical and have not shown significant changes, it is reasonable to continue with regular monitoring. The key is to remain vigilant for any new symptoms or changes in the lymph nodes, such as increased size, tenderness, or the development of new lymph nodes. If you experience any of these changes, or if you have concerns about your lymph nodes, it is advisable to consult your healthcare provider for further evaluation.

In summary, benign lymphoid hyperplasia can present with persistent and hard lymph nodes, and this is not inherently abnormal. However, ongoing observation is crucial, and any changes should prompt further evaluation. Regular follow-ups with your healthcare provider will ensure that any potential issues are addressed promptly. If you have any further concerns or questions, do not hesitate to reach out to your medical team for personalized advice and guidance.

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