Digestive Issues After Antibiotic Use: When to Seek Help - Gastroenterology and Hepatology

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Bowel issues


I started taking a lot of antibiotics two weeks ago due to illness, and since last week, I have been experiencing diarrhea after finishing the medication.
However, even four days after stopping the medication, I still continue to have diarrhea.
When I have abdominal pain and go to the bathroom, small pieces come out first, followed by larger soft stools, with at least five bowel movements throughout the day.
In the following days, the frequency decreased, but the stool had a white outer layer, while the inside appeared brown with some red.
What could this condition be? Should I see a doctor for an examination? Is there a possibility that this could be colon cancer?

Sunny, 20~29 year old female. Ask Date: 2016/06/16

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello, antibiotics can often disrupt the balance of gut bacteria, leading to diarrhea.
In the short term, a light diet and gastrointestinal medications can help alleviate the diarrhea.
However, if there is blood in the stool or a fever, a colonoscopy is necessary.
Changhua Hospital cares about your health.
Chen Shidian

Reply Date: 2016/06/16

More Info


After a course of antibiotics, it is not uncommon for individuals to experience digestive issues, including diarrhea. This condition is often referred to as antibiotic-associated diarrhea (AAD). Antibiotics can disrupt the natural balance of bacteria in the gut, leading to an overgrowth of harmful bacteria such as Clostridium difficile (C. diff), which can cause more severe gastrointestinal symptoms.

In your case, the persistent diarrhea, especially after stopping the antibiotics, raises some concerns. The presence of small, soft stools and the description of your bowel movements, particularly the white layer and the mixed colors, could indicate several possibilities:
1. Antibiotic-Associated Diarrhea: This is the most likely cause, especially if you have been taking broad-spectrum antibiotics. The disruption of gut flora can lead to diarrhea that persists even after stopping the medication.

2. C. difficile Infection: If the diarrhea is severe, persistent, and accompanied by abdominal pain, it could be a sign of a C. difficile infection, which can occur after antibiotic use. This infection can cause significant gastrointestinal distress and requires specific treatment.

3. Irritable Bowel Syndrome (IBS): Some individuals may develop IBS-like symptoms after antibiotic use, characterized by changes in bowel habits, including diarrhea.

4. Food Intolerances or Allergies: Sometimes, the gut can become more sensitive after antibiotic treatment, leading to intolerances to certain foods that may not have been problematic before.

5. Other Gastrointestinal Conditions: While it is less common, the symptoms you describe could also be indicative of other gastrointestinal issues, including inflammatory bowel disease (IBD) or, in rare cases, malignancies such as colorectal cancer. However, the likelihood of cancer is generally low in younger individuals without other risk factors.

Given your symptoms, it is advisable to seek medical attention. A healthcare provider can perform a thorough evaluation, which may include a physical examination, a review of your medical history, and possibly laboratory tests or imaging studies to determine the cause of your symptoms. They may also recommend a stool test to check for pathogens like C. difficile.

In summary, while antibiotic use can lead to temporary digestive issues, the persistence of your symptoms warrants further investigation. It is essential to consult with a healthcare professional to rule out any serious conditions and to receive appropriate treatment. Early intervention can help prevent complications and restore your gut health.

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