Loss of Appetite After Starting Antibiotics for Stomach Ulcers - Surgery

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Loss of appetite after starting antibiotics for a gastric ulcer?


Hello Doctor, I am the one who previously asked question #182881.
Since last night, I have been feeling very bloated and nauseous.
The feeling of nausea has decreased, but I still feel like vomiting and have completely lost my appetite.
Normally, I can finish my lunch, but today I could only eat half.
I would like to know if my current condition is caused by the antibiotics.
Before I started taking antibiotics, my appetite was quite good.
Currently, I am taking: 1.
Gastrointestinal motility agent (Gastrointestinal Relaxant) four times a day after meals and before bedtime; 2.
Prokinetic agent (Nizatidine) twice a day before breakfast and dinner; 3.
Antacid (Simethicone) four times a day after meals and before bedtime; 4.
Erythromycin twice a day after breakfast and dinner; 5.
Amoxicillin 500 mg four times a day after meals and before bedtime.

Mr. Hong, 20~29 year old female. Ask Date: 2022/06/13

Dr. Ke Fangxu reply Surgery


Oral antibiotics are used to treat Helicobacter pylori infections.
While these antibiotics kill stomach bacteria, they can also cause gastrointestinal discomfort, and some patients may experience diarrhea.
These are all temporary side effects.
To completely eradicate Helicobacter pylori, it is essential to complete the full course of treatment.
Once the antibiotics are finished, the discomfort will subside.

Reply Date: 2022/06/13

More Info


Loss of appetite after starting antibiotics for stomach ulcers can be a concerning side effect, and it’s important to understand the potential reasons behind this change. Based on your description, it seems that you have been prescribed a combination of medications, including gastric acid suppressants and antibiotics, to treat your stomach ulcer and possibly an associated infection.
Antibiotics, such as clarithromycin and amoxicillin, are commonly used to eradicate Helicobacter pylori, a bacterium often implicated in the development of stomach ulcers. While these medications are effective in treating the infection, they can also lead to gastrointestinal side effects, including nausea, vomiting, and loss of appetite. This is due to the way antibiotics can disrupt the normal balance of gut bacteria, leading to gastrointestinal discomfort.

In your case, the feeling of bloating and nausea, along with a significant decrease in appetite, could indeed be linked to the antibiotics you are taking. The combination of medications you are on—Gastric Comfort (胃逆舒), Nexium (耐適恩), and the antibiotics—can also contribute to gastrointestinal side effects. Nexium, a proton pump inhibitor, is effective in reducing stomach acid, which can help heal ulcers but may also lead to changes in digestion and appetite.

Here are some considerations and strategies to manage your symptoms:
1. Timing and Dosage: Ensure that you are taking your medications exactly as prescribed. Sometimes, adjusting the timing of when you take your medications in relation to meals can help mitigate nausea. For example, taking antibiotics with food can sometimes reduce gastrointestinal upset.

2. Dietary Adjustments: Since you are experiencing nausea and loss of appetite, it may be beneficial to consume smaller, more frequent meals rather than three large ones. Focus on bland, easy-to-digest foods such as toast, rice, bananas, and applesauce. Avoid spicy, fatty, or highly acidic foods that could exacerbate your symptoms.

3. Hydration: Staying hydrated is crucial, especially if you are feeling nauseous. Sipping on clear fluids, such as water, herbal teas, or clear broths, can help keep you hydrated without overwhelming your stomach.

4. Probiotics: Consider discussing with your healthcare provider the possibility of incorporating probiotics into your regimen. Probiotics can help restore the balance of good bacteria in your gut, which may be disrupted by antibiotic use. This could potentially alleviate some gastrointestinal symptoms.

5. Communication with Your Doctor: It’s essential to keep your healthcare provider informed about your symptoms. If your loss of appetite and nausea persist or worsen, your doctor may need to reassess your treatment plan. They might consider adjusting your medications or exploring other underlying causes for your symptoms.

6. Monitoring Symptoms: Keep a diary of your symptoms, noting when they occur and their severity. This information can be valuable for your healthcare provider in determining the best course of action.

In conclusion, while loss of appetite and nausea can be common side effects of antibiotics, it’s important to monitor your symptoms closely. If these issues continue, or if you experience any severe symptoms such as vomiting, severe abdominal pain, or signs of dehydration, you should seek medical attention promptly. Your healthcare provider can help determine the best approach to manage your symptoms while ensuring effective treatment for your stomach ulcer.

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