Persistent Oral Injury: When to Seek Biopsy for Healing Concerns? - Dentistry

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The inside of the left cheek has a bite wound that has not healed for about two weeks?


During the Dragon Boat Festival holiday, I accidentally bit my cheek with my left teeth, and the next day, a wound-like red mark appeared.
This subsequently developed into recurrent aphthous ulcers (with a red swollen outer ring and a white mucosal center).
As of the last two to three days, the irritation and pain have significantly decreased, but the wound still exists (I can faintly feel that the white mucosa has lightened).
During this time, I have applied two types of oral ointments, Ningkang and Aikou (not daily).
When I palpate both sides of my neck, there are no lumps.
I personally do not smoke, chew betel nut, or drink alcohol.
I have a history of recurrent aphthous ulcers, and the healing time varies, but the main concern is that the wound has persisted for two weeks, and I am worried it might be cancerous.
Should I undergo a biopsy? As shown in the image: (taken on June 22, 2016) http://imgur.com/KzmT26p

Mr. Lin, 30~39 year old female. Ask Date: 2016/06/22

Dr. Zeng Guanghui reply Dentistry


The wound from the bite on the inside of the left cheek has developed into an oral ulcer and has not fully healed for two weeks.
You can assess for any swelling or pain and adjust your lifestyle accordingly, making sure to avoid staying up late, get sufficient sleep, and manage stress levels.
If you still have concerns, you may consult a dentist for further examination.

Reply Date: 2016/06/22

More Info


When dealing with persistent oral injuries, especially those that have not healed within a typical timeframe, it is crucial to approach the situation with caution and seek appropriate medical advice. In your case, you mentioned that you sustained an injury to your cheek from biting it, which subsequently developed into a recurrent ulcer. This type of ulcer, characterized by a red inflamed border and a white necrotic center, is often associated with conditions like aphthous stomatitis, but it can also be a sign of other underlying issues.

The fact that your ulcer has persisted for over two weeks is noteworthy. Generally, most oral ulcers heal within 1 to 2 weeks. If an ulcer does not show signs of healing after this period, it raises concerns that warrant further investigation. The symptoms you described, including the reduction in pain and the change in the appearance of the ulcer, are positive signs, but they do not eliminate the need for caution.

Given your history of recurrent oral ulcers and the current situation, it is advisable to consult with a healthcare professional, preferably an oral surgeon or an otolaryngologist (ENT specialist), who can perform a thorough examination. They may recommend a biopsy if they suspect that the ulcer could be indicative of a more serious condition, such as oral cancer or another pathological process. A biopsy is a relatively straightforward procedure that involves taking a small sample of tissue from the ulcer for histological examination. This can provide definitive information about the nature of the lesion.

In terms of your concerns about cancer, it is important to note that while persistent ulcers can be a sign of malignancy, they are more commonly associated with benign conditions. Factors such as smoking, alcohol use, and certain systemic diseases can increase the risk of oral cancers, but you mentioned that you do not engage in these behaviors, which is a positive factor.

In addition to seeking a biopsy, consider the following recommendations for managing your oral health:
1. Maintain Oral Hygiene: Keeping your mouth clean can help prevent secondary infections. Use a soft-bristled toothbrush and avoid irritating the area.

2. Avoid Irritants: Stay away from spicy, acidic, or abrasive foods that may exacerbate the ulcer.

3. Topical Treatments: Continue using topical medications as prescribed or recommended by your healthcare provider. These can help alleviate pain and promote healing.

4. Monitor Symptoms: Keep track of any changes in the ulcer, including size, color, and associated symptoms like pain or swelling. This information will be valuable for your healthcare provider.

5. Follow-Up: If the ulcer does not improve or worsens, return to your healthcare provider for further evaluation.

In conclusion, while it is understandable to be concerned about the possibility of malignancy, the best course of action is to consult with a medical professional who can provide a thorough assessment and determine whether a biopsy is necessary. Early detection and intervention are key in managing any potential oral health issues, and your proactive approach to seeking help is commendable.

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