Does Mecon Cream Cause Ototoxicity? Concerns About Ear Health - Otolaryngology

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Is Meikang ointment potentially ototoxic?


Recently, I visited an ENT clinic due to pain in my ear.
The doctor applied a cream called Mecon ointment inside my ear using a cotton swab.
After researching online, I discovered that it contains Neomycin (as sulfate) and Gramicidin, particularly noting that Neomycin has ototoxic properties that can lead to neuropathy and irreversible hearing loss.
I'm really worried and don't know what to do, especially since I'm unsure if I have a perforated eardrum.
Could this lead to more severe complications?

Nǐ hǎ, 20~29 year old female. Ask Date: 2016/06/26

Dr. Zheng Jueyi reply Otolaryngology


Hello: Generally, topical ointments do not come into contact with the inner ear, so there is no need to worry about ototoxicity.
Wishing you safety and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2016/06/26

More Info


Mecon Cream, which contains Neomycin and Gramicidin, has raised concerns regarding its potential ototoxicity, especially when applied in the ear canal. Ototoxicity refers to the property of certain substances to cause damage to the inner ear, leading to hearing loss or balance issues. Neomycin, in particular, is known for its ototoxic effects, especially when used inappropriately or in patients with pre-existing ear conditions.

In your case, it is understandable to feel anxious after discovering the potential risks associated with the cream used in your ear. Neomycin can indeed cause irreversible damage to the auditory nerve, leading to hearing loss, particularly if the eardrum is perforated or if the medication is absorbed into the inner ear. However, it is important to note that the risk of ototoxicity is significantly lower when the medication is applied topically and does not come into contact with the inner ear structures.

If you are concerned about the possibility of a perforated eardrum, it is crucial to seek medical attention. A healthcare professional can perform an otoscopic examination to determine the integrity of your eardrum. If there is a perforation, they can provide guidance on how to manage the situation and prevent further complications. In cases where the eardrum is intact, the risk of ototoxicity from topical application is generally minimal, but monitoring for any unusual symptoms such as hearing changes, tinnitus (ringing in the ears), or balance issues is advisable.

In the meantime, if you experience any discomfort, pain, or changes in your hearing, do not hesitate to contact your healthcare provider. They may recommend stopping the use of the cream and possibly prescribe an alternative treatment that does not carry the same risks. Additionally, if you have any underlying conditions that may predispose you to ear problems, such as a history of ear infections or previous ear surgeries, it is essential to inform your doctor.

In summary, while Mecon Cream does contain ingredients that have the potential for ototoxicity, the actual risk depends on various factors, including the condition of your eardrum and the method of application. It is always best to err on the side of caution and consult with a healthcare professional if you have any concerns about your ear health. Taking proactive steps to monitor your symptoms and seeking medical advice can help alleviate your worries and ensure your ear health is properly managed.

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