Abdominal Pain and Weight Loss: Gastrointestinal Concerns - Gastroenterology and Hepatology

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Abdominal pain and weight loss can be concerning symptoms that warrant thorough investigation, especially when they persist over time. Based on your description, it seems you have been experiencing intermittent abdominal discomfort, changes in bowel habits, and significant weight loss over a three-month period. These symptoms can be indicative of various gastrointestinal issues, and understanding the underlying causes is crucial for effective management.

Firstly, the intermittent nature of your abdominal pain, along with the changes in bowel habits—specifically the soft and sometimes unformed stools—suggests a possible functional gastrointestinal disorder, such as irritable bowel syndrome (IBS). IBS is characterized by abdominal pain and altered bowel habits, which can include diarrhea, constipation, or a mix of both. Stress and dietary changes can exacerbate these symptoms, and it’s important to consider any lifestyle factors that may contribute to your condition.

The significant weight loss of approximately 13 kilograms (about 28.6 pounds) in three months is particularly concerning. Unintentional weight loss can be a red flag for more serious underlying conditions, such as inflammatory bowel disease (IBD), infections, or even malignancies. Although you have undergone various tests, including endoscopies and stool tests, and have been prescribed medications, the persistence of your symptoms indicates that further evaluation may be necessary.

The presence of antibodies for amoebic infection, despite negative PCR results, raises the question of whether there might be a chronic infection or inflammation that has not been fully addressed. It’s also worth noting that the findings of localized inflammation in your gastrointestinal tract could suggest conditions like gastritis or colitis, which may require targeted treatment beyond general gastrointestinal medications.

In terms of dietary management, it’s commendable that you have adopted a healthier diet, focusing on low-fat and low-sugar foods. However, it may be beneficial to work with a registered dietitian who specializes in gastrointestinal health. They can help you identify any potential food intolerances or sensitivities that could be contributing to your symptoms. For instance, some individuals with gastrointestinal issues may benefit from a low-FODMAP diet, which can help reduce bloating and discomfort.

Additionally, since you mentioned taking supplements like glutamine and curcumin, it’s essential to ensure that these are appropriate for your specific condition. While glutamine may help with gut health and curcumin has anti-inflammatory properties, it’s crucial to discuss these with your healthcare provider to ensure they align with your treatment plan.

Given the complexity of your symptoms and the lack of improvement despite treatment, I recommend seeking a second opinion from a gastroenterologist, preferably one who specializes in functional gastrointestinal disorders. They may suggest further diagnostic tests, such as imaging studies or additional blood tests, to rule out any underlying conditions that may not have been previously identified.

In summary, your symptoms of abdominal pain, changes in bowel habits, and significant weight loss warrant a comprehensive evaluation. It’s essential to continue working closely with your healthcare team, advocate for yourself, and explore all potential avenues for diagnosis and treatment. Keeping a detailed symptom diary, including food intake, stress levels, and any other relevant factors, can also provide valuable insights for your healthcare provider. Remember, you are not alone in this journey, and with the right support and investigation, you can find a path toward relief and improved health.