Antibiotics and Their Impact on Kidney and Urinary Health - Urology

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Antibiotics and Kidney and Urinary Issues


Hello, Doctor.
I just finished a 10-day course of Crumanoquin dissolvable tablets (antibiotics) prescribed by my doctor five days ago.
However, five days later, my urine is very yellow, and sometimes my body, especially my fingers or feet, develops red, itchy hives that sometimes disappear by morning, but some remain.
I had a urine test yesterday afternoon, and the doctor said there were no issues, but it wasn't the first morning urine.
Is that accurate?

Mr. Zhang, 10~19 year old female. Ask Date: 2016/07/15

Dr. Lin Wenxu reply Urology


1.
After taking the medication, if a rash resembling hives appears, it may be necessary to consider a drug allergy reaction.
2.
If the urine color is yellowish, it may indicate insufficient fluid intake.
3.
Urine tests can generally be done in the morning or afternoon.
Unless there is a specific purpose, the first or second morning urine is not required.
Thank you.

Reply Date: 2016/07/15

More Info


Antibiotics are powerful medications used to treat bacterial infections, but their use can have various effects on the body, particularly the kidneys and urinary health. When antibiotics are prescribed, it is essential to understand both their benefits and potential side effects.

Firstly, the kidneys play a crucial role in filtering and excreting medications, including antibiotics. Most antibiotics are eliminated from the body through the kidneys, which means that if there is any pre-existing kidney dysfunction, the clearance of these drugs can be impaired. This can lead to higher levels of the medication in the bloodstream, increasing the risk of side effects and toxicity. For instance, certain antibiotics, such as aminoglycosides, can be nephrotoxic, meaning they can cause damage to the kidneys, especially when used in high doses or for prolonged periods.

In your case, after completing a 10-day course of an antibiotic, you are experiencing symptoms such as yellow urine and skin reactions resembling hives. Yellow urine can be a result of dehydration, concentrated urine, or the presence of certain medications. Antibiotics can also alter the normal flora of the gut and urinary tract, potentially leading to changes in urine color and consistency. The skin reactions you describe could be an allergic response to the antibiotic or another substance, and it is essential to monitor these symptoms closely.

Regarding your urine test results, it is important to note that the first morning urine is often the most concentrated and can provide a more accurate assessment of certain conditions, such as proteinuria or hematuria. If your doctor stated that there were no issues with your urine test, it suggests that there were no significant abnormalities detected at that time. However, if you continue to experience symptoms or if the skin reactions worsen, it would be prudent to follow up with your healthcare provider for further evaluation.

In addition to the direct effects of antibiotics on the kidneys, other factors can contribute to kidney health. For example, a high-protein diet, as mentioned in previous discussions, can place additional strain on the kidneys, particularly if there is an underlying condition. Staying well-hydrated is crucial, especially when taking medications that can affect kidney function.

To summarize, while antibiotics are essential for treating infections, they can have implications for kidney and urinary health. It is vital to communicate any unusual symptoms to your healthcare provider, who can assess whether these are related to the antibiotic treatment or if they may indicate another underlying issue. Regular monitoring of kidney function, especially if you have risk factors or pre-existing conditions, is also advisable. Always consult your doctor before making any changes to your medication or diet, and ensure that you are following their recommendations for follow-up care.

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