Hepatitis B Test Results: Should You Pay for Further Testing? - Gastroenterology and Hepatology

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Hepatitis B..?


Hello Doctor, I did not pass the military service physical examination and was asked to undergo a re-examination.
Therefore, I spent 1500 NTD at a clinic for a blood test to check my liver.
After the results came out, the doctor said my report was very unreasonable (specifically, HBsAg Positive (5.96), with a reference value of <0.05 Negative; the doctor mentioned that normal hepatitis B patients have values in the thousands, while mine is only five).
He prescribed Silymarin capsules for me to take and advised me to consult with a doctor during the military re-examination...
(Later, I found out that the re-examination only involves blood tests and there won't be a doctor present).
He also suggested that I consider paying 2500 NTD out of pocket for a hepatitis B DNA viral load test, which left me very troubled, as it's not a small amount of money, and I'm uncertain about my health condition (ALT is over twice the normal limit).

1.
Should I spend 2500 NTD for the test?
2.
Is it possible that the HBsAg value of 5.96 is a false positive?
3.
The doctor mentioned that if the hepatitis B DNA test does not explain the situation, I would need to spend an additional two thousand NTD for a complete liver examination...
I'm unsure of what to do...
Thank you, doctor, for addressing my long-standing concerns.
I appreciate it.

My report's relevant values:
- AST: 43 (reference range: 5-34)
- ALT: 114 (reference range: 0-55)
- A/G ratio: 2.0 (reference range: 1.0-1.8)
- HBsAg: positive (5.96) (reference range: <0.05 Negative)
- Anti-HBs: Negative (1.18) (reference range: <10 Negative)
- HBeAg: Negative (0.299) (reference range: <1.0 Negative)
(Hepatitis A and C are both negative, and the doctor ruled out drug-induced and alcoholic hepatitis; abdominal ultrasound is normal.)

Mr. Wang, 20~29 year old female. Ask Date: 2016/09/09

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello, you can visit a large hospital's gastroenterology department for follow-up examinations.
If your ALT levels continue to rise without decreasing, you may also consider having a DNA test covered by health insurance.
Changhua Hospital cares about your health.
Chen Shidian.

Reply Date: 2016/09/09

More Info


When interpreting your Hepatitis B test results, it’s essential to understand the significance of each marker and the implications for your health. Based on the information you've provided, your HBsAg (Hepatitis B surface antigen) level is 5.96, which is above the negative threshold of <0.05. This indicates that you are currently infected with the Hepatitis B virus (HBV), but the low level of HBsAg suggests that you may not have a high viral load, which is often seen in chronic infections.
1. Should You Pay for Further Testing?
Given your current HBsAg level and elevated ALT (alanine aminotransferase) of 114, which is more than double the normal range, it is advisable to proceed with further testing, including the HBV DNA test. This test will quantify the amount of virus in your blood and help determine the level of viral replication. Knowing your viral load is crucial for assessing the severity of your infection and deciding on the need for treatment. The cost of 2500 TWD for this test may seem high, but it is a necessary investment in understanding your health status and guiding future management.

2. Is HBsAg 5.96 a Possible False Positive?
While false positives can occur in any laboratory test, the context of your results suggests that this is unlikely. The HBsAg test is generally reliable, and your positive result, combined with elevated liver enzymes, points towards an active infection. However, it is always prudent to discuss the possibility of retesting with your healthcare provider, especially if there are concerns about the accuracy of the initial test.

3. Further Testing and Costs:
If the HBV DNA test indicates a significant viral load, your healthcare provider may recommend additional tests to assess liver function and damage, such as a complete liver panel or even a liver biopsy to evaluate fibrosis or cirrhosis. While these additional tests may incur further costs, they are critical for determining the appropriate treatment strategy.
In summary, your current situation warrants further investigation. The combination of a positive HBsAg, elevated ALT levels, and the potential risk factors you mentioned (such as family history of liver disease) makes it essential to have a comprehensive understanding of your liver health. Engaging with a specialist in hepatology or infectious diseases can provide you with tailored advice and management options.

Additionally, it’s important to maintain regular follow-ups and monitor your liver function over time. If you are diagnosed with chronic Hepatitis B, there are effective antiviral treatments available that can help manage the infection and reduce the risk of liver complications, including cirrhosis and liver cancer. Early intervention can significantly improve outcomes, so taking proactive steps now is crucial for your long-term health.

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