Safe Medications for Pregnant Women: What You Need to Know - Pharmacology

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Medications during pregnancy: I would like to know if these medications are safe for use by pregnant women?


Hello, I am currently 12 weeks and 4 days pregnant.
I accidentally caught a cold and have seen a doctor, but I still feel anxious and uncertain about whether these medications are within a safe range.
The names of the medications are as follows: CHYMOTRYPSIN, Johnson's TIPEPIDINE 20MG, Taiwan ACETAMINOPHEN (PARACETAMOL), CARBINOXAMINE MALEATE, Johnson's DIMETHICONE (DIMETH).

Pao Pao, 20~29 year old female. Ask Date: 2016/09/24

Dr. Liao Huiling reply Pharmacology


Among the five medications you inquired about, only ACETAMINOPHEN is classified as Pregnancy Category B, while the other medications are classified as Pregnancy Category C.
The explanations for the pregnancy categories are as follows:
Category A: No evidence of risk to the fetus in human studies; these medications are considered safe.
There have been controlled studies in humans, and the likelihood of harm to the fetus is minimal.
Vitamins fall into this category.
There are very few medications in this category because studies involving pregnant women are rare.
Category B: Animal studies have shown no risk to the fetus, but there are no controlled studies in pregnant women.
Additionally, some animal studies may indicate adverse effects on the fetus, but controlled studies in pregnant women have not confirmed any harm to the fetus from these medications.
Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.
Some medications have not been tested in animals or humans.
Medications in this category should only be used if the potential benefits to the fetus outweigh the potential risks, and careful consultation with an obstetrician is advised.
Category D: There is sufficient evidence of risk to the fetus, but if the benefits of the medication to the pregnant woman are deemed to outweigh the risks to the fetus, it may still be used.
Category X: Both animal and human studies have shown evidence of fetal abnormalities, indicating a risk to the fetus.
Medications in this category are absolutely contraindicated in pregnant women, such as isotretinoin (for acne treatment), thalidomide, and certain cholesterol-lowering medications.

Reply Date: 2016/09/24

More Info


When it comes to medication safety during pregnancy, it's crucial to understand that the effects of drugs can vary significantly depending on the stage of pregnancy and the specific medication in question. Pregnant women often experience anxiety about the medications prescribed to them, especially in the first trimester when fetal development is most critical.
In your case, you mentioned that you are currently 12 weeks and 4 days pregnant and have been prescribed the following medications: Chymotrypsin, Tipepidine 20mg, Acetaminophen (also known as Paracetamol), CarbinoXamine Maleate, and Dimethicone. Let’s break down each of these medications in terms of their safety during pregnancy.

1. Chymotrypsin: This is an enzyme that helps in the digestion of proteins. While there is limited data on its use during pregnancy, it is generally considered safe when used as directed. However, it is always best to consult your healthcare provider regarding its necessity and safety.

2. Tipepidine 20mg: Tipepidine is an antitussive (cough suppressant) that is sometimes used to relieve cough. There is limited information on its safety during pregnancy, and it is classified as a category C drug, which means that risk cannot be ruled out. It is advisable to use this medication only if the benefits outweigh the risks and under the guidance of your physician.

3. Acetaminophen (Paracetamol): This is one of the most commonly used pain relievers and fever reducers during pregnancy. It is generally considered safe and is classified as a category B medication, meaning that there is no evidence of risk to the fetus in human studies. However, it should be used at the recommended doses and not for prolonged periods without medical advice.

4. CarbinoXamine Maleate: This is an antihistamine used to relieve allergy symptoms. It is classified as a category B drug, indicating that it is generally safe for use during pregnancy. However, like all medications, it should be used judiciously and only when necessary.

5. Dimethicone: This is an anti-foaming agent used to relieve bloating and discomfort caused by excess gas. It is considered safe during pregnancy and is often used in over-the-counter medications for digestive issues.

In summary, while some of the medications you have been prescribed are generally considered safe during pregnancy, it is essential to have a thorough discussion with your healthcare provider about the necessity of each medication, especially since you are in the early stages of pregnancy. Your doctor can provide guidance tailored to your specific health needs and the health of your developing baby.

Additionally, it is important to remember that non-pharmacological approaches can also be effective in managing mild symptoms of illness during pregnancy. Staying hydrated, getting plenty of rest, and using saline nasal sprays for congestion can often help alleviate symptoms without the need for medication.

Lastly, always inform your healthcare provider about any other medications or supplements you are taking, as well as any allergies or previous adverse reactions to medications. This information is crucial for ensuring the safety and well-being of both you and your baby during this important time.

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