Managing Medication Side Effects in Severe Depression: What to Do? - Psychiatry

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Medications for Depression


I have severe depression and have been on medication for six months, but I stopped taking it on my own for over a month without fully recovering.
I decided to return for a follow-up appointment recently because I will be going back to my work environment next month, which brings a lot of worries and fears.
I feel like I might completely lose control under stress.
I started taking the medication again a few days ago, and I have a feeling that after dinner, I need to take a 60mg dose of Venlafaxine.
When I swallow it, I feel very nauseous and end up vomiting everything I ate for dinner.
Therefore, I am concerned that if I vomit the medication, it won't be effective.
I take 25mg of Quetiapine before bed, and I fall asleep quickly after taking it.
I just want to ask if the nausea and vomiting after taking the medication is a side effect or if it's a psychological barrier preventing me from taking the medication.
How should I address this issue?

Niming, 20~29 year old female. Ask Date: 2016/09/24

Dr. Liang Sunyuan reply Psychiatry


Hello: Some individuals may experience gastrointestinal discomfort as a side effect of taking Amitriptyline.
If this issue persists, it is advisable to return to the clinic and discuss with a physician whether a dosage adjustment or a switch to another medication is necessary.

Reply Date: 2016/09/24

More Info


Managing medication side effects in severe depression can be a complex and challenging process, especially when dealing with the emotional and physical symptoms that accompany both the condition and the treatment. Your experience of feeling nauseous and vomiting after taking your medication is concerning and warrants careful consideration.

Firstly, it’s important to understand that nausea and vomiting can be common side effects of certain antidepressants, including medications like Venlafaxine (often referred to as "萬憂停"). These side effects can sometimes diminish over time as your body adjusts to the medication. However, if these symptoms are severe or persistent, they can significantly impact your ability to adhere to your treatment plan, which is crucial for managing depression effectively.

Given your situation, here are several steps you can take to address the issue:
1. Consult Your Doctor: The first and most important step is to communicate openly with your psychiatrist or healthcare provider about the side effects you are experiencing. They can assess whether the nausea is a side effect of the medication or if it might be related to anxiety about taking the medication. Your doctor may consider adjusting the dosage, switching to a different medication, or prescribing an anti-nausea medication to help alleviate this side effect.

2. Timing and Food: Sometimes, taking medication with food can help reduce gastrointestinal side effects. If you are taking your medication after dinner and experiencing nausea, you might want to try taking it with a lighter meal or a snack instead. Additionally, some medications are better tolerated when taken at bedtime rather than during the day, so discuss this option with your doctor.

3. Gradual Reintroduction: Since you had previously stopped your medication for over a month, your body may need time to readjust. If you are feeling overwhelmed by the side effects, consider discussing a gradual reintroduction of the medication with your doctor. This might involve starting at a lower dose and slowly increasing it as tolerated.

4. Psychological Factors: It’s also possible that anxiety about taking the medication is contributing to your nausea. Cognitive-behavioral strategies can be helpful in addressing these feelings. Techniques such as mindfulness, relaxation exercises, and cognitive restructuring can help reduce anxiety and improve your comfort with taking medication.

5. Support System: Engaging with a support system, whether it be friends, family, or a support group, can provide emotional backing as you navigate your treatment. Sharing your experiences and feelings can help alleviate some of the burdens you may be feeling.

6. Monitoring Symptoms: Keep a journal of your symptoms, including when you take your medication, what you eat, and how you feel afterward. This information can be invaluable for your healthcare provider in determining the best course of action.

7. Consider Therapy: In addition to medication, therapy can be an effective component of treatment for depression. Cognitive-behavioral therapy (CBT) or other forms of psychotherapy can help you develop coping strategies for managing anxiety and depression, which may, in turn, help with medication adherence.

8. Emergency Plan: If you find yourself in a situation where you feel overwhelmed or unable to cope, having a plan in place for seeking immediate help can be beneficial. This could include knowing when to reach out to your healthcare provider or having a trusted friend or family member to contact.

In conclusion, managing medication side effects in severe depression requires a multifaceted approach that includes open communication with your healthcare provider, potential adjustments to your treatment plan, and psychological support. It’s essential to address both the physical and emotional aspects of your treatment to achieve the best possible outcome. Remember, you are not alone in this journey, and there are resources and support available to help you navigate these challenges.

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