Side Effects of Blood Pressure Medications: A Pharmacist's Insight - Pharmacology

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Medication Consultation


Hello, pharmacist.
I previously took Lisinopril 160 mg for high blood pressure, but my clinic recently switched my medication to Diltiazem 160 mg.
After taking it in the morning, I often experience symptoms of nausea and a strange taste in my throat, which I did not have before switching medications.
Could this new medication be causing these symptoms?

Mr. Tsai, 40~49 year old female. Ask Date: 2016/10/16

Dr. Liao Lingmei reply Pharmacology


Hello: The main ingredients of Fulexin enteric-coated tablets and Deyayue enteric-coated tablets are the same, and the manufacturer of Deyayue has also passed the bioequivalence test for this medication.
Before identifying the cause, it is essential to confirm that if you stop taking Deyayue enteric-coated tablets, the feelings of nausea or unpleasant taste will disappear.
There could be several possible reasons for this, such as the addition of excipients during the manufacturing process, but without a clear cause, it cannot be attributed or blamed.
If the side effects significantly impact your quality of life and reduce your willingness to continue the medication, you may discuss this further with your physician for an evaluation of your treatment.
Wishing you health and happiness!

Reply Date: 2016/10/16

More Info


When it comes to managing high blood pressure, the choice of medication can significantly impact both efficacy and side effects. In your case, you mentioned switching from a medication called "樂心膜衣錠" (likely a brand name for a specific antihypertensive) to "德壓悅膜衣錠," and experiencing symptoms such as nausea and an unusual taste in your throat after taking the new medication.
Firstly, it's important to understand that different antihypertensive medications can have varying side effects based on their active ingredients and mechanisms of action. Both medications you mentioned likely belong to the class of drugs known as calcium channel blockers or possibly other antihypertensive classes, but the specific active ingredients can lead to different side effects.
Nausea and a strange taste in the throat can indeed be side effects associated with certain antihypertensive medications. For instance, some calcium channel blockers can cause gastrointestinal disturbances, including nausea, due to their effects on smooth muscle relaxation in the gastrointestinal tract. Additionally, medications can sometimes lead to a metallic or unusual taste, which may be related to the drug's formulation or the way it interacts with your body.

If you previously did not experience these symptoms while on the prior medication, it is possible that the new medication is not as well tolerated by your body. It is also worth noting that individual responses to medications can vary widely; what works well for one person may not work as effectively or may cause side effects in another.

Here are a few considerations and recommendations:
1. Consult Your Healthcare Provider: It is crucial to discuss these new symptoms with your prescribing physician or pharmacist. They can assess whether the symptoms are likely related to the new medication and determine if a change in treatment is necessary.

2. Monitor Symptoms: Keep a record of when you experience these symptoms, their severity, and any other changes in your health. This information can be valuable for your healthcare provider in making decisions about your treatment.

3. Consider Timing and Food Interactions: Sometimes, the timing of medication (e.g., taking it with or without food) can influence side effects. If you are taking the medication on an empty stomach, it might be worth trying to take it with food to see if that alleviates the nausea.

4. Hydration and Diet: Ensure you are staying well-hydrated and maintaining a balanced diet, as dehydration or certain dietary choices can exacerbate gastrointestinal symptoms.

5. Review Other Medications: If you are taking other medications or supplements, consider discussing them with your healthcare provider, as interactions can sometimes lead to unexpected side effects.

6. Long-term Management: High blood pressure is often a chronic condition requiring ongoing management. If a particular medication is not suitable, there are many alternatives available. Your healthcare provider can help find a medication that effectively controls your blood pressure while minimizing side effects.

In summary, while it is not uncommon for new medications to cause side effects that were not present with previous treatments, it is essential to communicate these changes to your healthcare provider. They can help determine the best course of action, whether that involves adjusting your current medication, switching to a different one, or implementing supportive measures to manage side effects. Your health and comfort are paramount, and there are many options available to effectively manage high blood pressure.

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