Kidney Function and Glomerular Filtration Rate Issues - Internal Medicine

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Glomerular and renal function issues?


Hello doctor, I would like to ask a question.
I am 35 years old, and my glomerular filtration rate (GFR) has not exceeded 90 for the past seven years.
I do not have hypertension or diabetes.
In my most recent urine test, the protein level was <6, which the doctor said is normal, and the urine glucose was also negative.
Other indices were considered normal.
I have a regular exercise routine and eat a balanced diet, although I occasionally indulge in large meals.
Recently, during a company health check, I noticed that my GFR has consistently been in the red for the past three years.
I remember that the health check report from three years ago did not include the GFR, but I have had serum creatinine values listed as shown in the table below.
I went to a large hospital for further testing, but the doctor did not clearly explain whether I have kidney issues.
He advised me to eat less meat, drink more water, and return for blood tests in three months.
I would like to know if there is a problem with my kidney function, or if the doctor has any other recommendations.
Thank you.
Health Check Year | Age | Serum Creatinine
2010 | 29 | 1.22
2011 | 30 | 1.32
2012 | 31 | 1.08
2013 | 32 | 1.07
2014 | 33 | 1.17
2015 | 34 | 1.18
2016 (June) | 35 | 1.17
2016 (October) | 35 | 1.09

Xiao Guo, 30~39 year old female. Ask Date: 2016/10/17

Dr. Wu Jiyu reply Internal Medicine


Based on the data you provided, the following is the calculation of the health examination results:
Year Age Serum Creatinine Glomerular Filtration Rate (GFR)
2010 29 1.2 mg/dL 72 mL/min
2011 30 1.3 mg/dL 65 mL/min
2012 31 1.08 mg/dL 80 mL/min
2013 32 1.07 mg/dL 80 mL/min
2014 33 1.17 mg/dL 72 mL/min
2015 34 1.18 mg/dL 71 mL/min
2016 (June) 35 1.17 mg/dL 71 mL/min
2016 (October) 35 1.09 mg/dL 77 mL/min
From your description, it can be inferred that you have some basic knowledge regarding the staging and management of chronic kidney disease (CKD).
Currently, the formula we use to calculate the Glomerular Filtration Rate (GFR) is the MDRD (Modification of Diet in Renal Disease) study equation, which was developed based on data from abroad.
It may require adjustments for application to our population (research is currently ongoing by local scholars).
However, according to your report, although your GFR is below 90, it remains stable (indicating Stage 2 Chronic Kidney Disease).
Regular check-ups in the future, monitoring for hypertension and diabetes, and avoiding unnecessary pain medications or dietary supplements are the best ways to maintain your health.

Thank you for your inquiry.
The Nephrology Department at Changhua Hospital cares about your well-being.

Reply Date: 2016/10/17

More Info


Understanding kidney function and glomerular filtration rate (GFR) is crucial for assessing renal health, especially as we age or if we have risk factors for kidney disease. Your concern regarding your GFR and creatinine levels is valid, and it's important to interpret these values in the context of your overall health.

The GFR is a measure of how well your kidneys are filtering blood. It is estimated using serum creatinine levels, age, sex, and sometimes race. A normal GFR is typically considered to be 90 mL/min/1.73 m² or higher. However, values between 60 and 89 can indicate mild kidney impairment, especially if there are other signs of kidney damage, such as proteinuria (protein in the urine) or hematuria (blood in the urine).

From your history, it appears that your GFR has consistently been below 90 over the past few years, which could indicate a trend of declining kidney function. Your creatinine levels, while fluctuating, have remained relatively stable, which is a positive sign. However, the fact that your GFR has not improved and has been in the lower range raises some concerns.

The presence of protein in your urine, even at low levels, can be a sign of kidney damage. The kidneys typically filter out waste while retaining proteins, so any protein detected in urine can indicate that the filtering mechanism is not functioning optimally. Your recent urine protein level of less than 6 mg/dL is within normal limits, but it’s essential to monitor this over time.

Your doctor’s advice to reduce meat intake and increase water consumption is sound. High protein diets can put additional strain on the kidneys, particularly in individuals with existing kidney concerns. Staying well-hydrated helps the kidneys function more effectively and can assist in flushing out waste products.

Given that you are physically active and maintain a balanced diet, you are already taking positive steps toward kidney health. However, it’s crucial to continue monitoring your kidney function through regular check-ups. Here are some additional recommendations:
1. Regular Monitoring: Continue to have your kidney function tested regularly, including serum creatinine and urine tests for protein. This will help track any changes in your kidney health.

2. Blood Pressure Control: High blood pressure can damage the kidneys over time. If you have not already, consider having your blood pressure checked regularly and discuss any necessary lifestyle changes or medications with your doctor.

3. Diabetes Management: If you have any risk factors for diabetes or elevated blood sugar levels, managing your blood sugar is crucial, as diabetes is a leading cause of kidney disease.

4. Dietary Adjustments: In addition to reducing meat intake, consider a diet low in sodium and processed foods. Increasing fruits and vegetables can provide essential nutrients while being lower in protein.

5. Hydration: Ensure you are drinking enough fluids daily, as this can help maintain kidney function.

6. Avoid Nephrotoxic Substances: Be cautious with over-the-counter medications, especially NSAIDs (like ibuprofen), as they can harm the kidneys if taken excessively.

7. Consult a Nephrologist: If your GFR continues to decline or if you have concerns about your kidney health, consider consulting a nephrologist for specialized care.

In summary, while your current kidney function may not be optimal, there are many proactive steps you can take to maintain and potentially improve your kidney health. Regular follow-ups with your healthcare provider will be essential in managing your kidney function effectively.

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