Impact of Thyroid Medication on Bone Healing After Fracture - Orthopedics

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Simultaneous use of Ontruzant and osteoporosis medications?


Hello Dr.
Tsai, my mother is 63 years old.
She had a femur fracture from a car accident six months ago.
Recently, during a follow-up appointment, the doctor mentioned that after six months, she should not be walking with a limp.
The X-ray showed that there is a void in one area of the bone, which may lead to a leg length discrepancy.
My mother has had her entire thyroid removed and is on medication.
Could the thyroid medication be causing her poor recovery?

Miss Zhu, 30~39 year old female. Ask Date: 2016/11/17

Dr. Cai Shanglin reply Orthopedics


Hello: There is a certain percentage of poor healing associated with femoral fractures, and the prognosis depends on the location of the fracture, the degree of comminution, and the surgical approach used, so it may not necessarily be related to thyroid medication.
There are several mechanisms of action for osteoporosis medications, and it is advisable to discuss with your orthopedic surgeon which medication is most suitable for you.

Reply Date: 2016/11/17

More Info


The concern regarding the impact of thyroid medication on bone healing, especially after a fracture, is a significant one, particularly for individuals who have undergone thyroid surgery, such as a total thyroidectomy. In your mother's case, her history of a femoral fracture and the subsequent healing challenges she is experiencing may indeed raise questions about the role of her thyroid medication in the healing process.

Thyroid hormones play a crucial role in bone metabolism. They are essential for the normal development and maintenance of bone tissue. An imbalance in thyroid hormone levels, whether due to hyperthyroidism or hypothyroidism, can adversely affect bone health. After a total thyroidectomy, patients typically require lifelong thyroid hormone replacement therapy to maintain normal metabolic function. The most commonly prescribed medication is levothyroxine, which is a synthetic form of the thyroid hormone thyroxine (T4).

In general, adequate levels of thyroid hormones are necessary for optimal bone healing. Hypothyroidism, or insufficient thyroid hormone levels, can lead to delayed bone healing and increased risk of fractures. Conversely, excessive levels of thyroid hormones (hyperthyroidism) can lead to bone loss and osteoporosis, which can also impair healing. Therefore, it is essential to monitor thyroid hormone levels closely in patients who have undergone thyroid surgery and are on replacement therapy.

In your mother's case, if her thyroid hormone levels are well-managed and within the normal range, it is less likely that her thyroid medication is directly causing her poor healing. However, if her levels are not adequately controlled, it could potentially contribute to her healing difficulties. Additionally, factors such as age, nutritional status (including calcium and vitamin D levels), the severity of the fracture, and the overall health of the bone prior to the injury also play critical roles in the healing process.

It is also worth noting that osteoporosis, which is common in postmenopausal women, can significantly affect bone healing. If your mother has osteoporosis, this could be a contributing factor to her delayed recovery. Medications for osteoporosis, such as bisphosphonates, can help improve bone density and may aid in healing, but they also require careful management and monitoring.

Given your mother's situation, it would be advisable to have a thorough discussion with her healthcare provider, including her endocrinologist and orthopedic surgeon. They can evaluate her thyroid hormone levels, assess her bone density, and determine if her current medication regimen is appropriate. If necessary, adjustments to her thyroid medication or the addition of osteoporosis treatment may be warranted to support her recovery.

In conclusion, while thyroid medication can influence bone healing, it is essential to consider the broader context of your mother's health, including her thyroid hormone levels, bone density, and overall medical history. Close monitoring and collaboration between her healthcare providers will be key to optimizing her recovery and ensuring that she regains her mobility and quality of life.

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