Is it safe to take retinoic acid if triglycerides and SGPT liver enzymes are elevated?
Hello Doctor, I have been struggling with acne on the side of my neck that won't heal.
A dermatologist recommended using retinoids, but I found information suggesting that they may not be suitable for individuals with elevated triglyceride levels.
I had blood work done at the end of September, and my ALT/SGPT liver enzyme level was 52 (reference range: 0-40) and my triglycerides were 251 (reference range: 0-150).
Given this, am I unsuitable for taking retinoids? Thank you for taking the time to answer my question.
Raymond, 20~29 year old female. Ask Date: 2016/11/22
Dr. Li Yufen reply Dermatology
Hello: Regarding oral isotretinoin, you can refer to Dr.
Wang Hsiu-Han's article at http://www.skin168.net/2013/09/oral-isotretinoin-effect-adverse.html.
It is not recommended to use oral isotretinoin for treatment in cases of liver dysfunction and elevated blood lipids.
Thank you!
Reply Date: 2016/11/22
More Info
When considering the use of A acid (isotretinoin) for treating skin issues such as persistent acne, it is crucial to take into account your current health status, particularly your elevated triglycerides and SGPT (ALT) levels. Isotretinoin is a powerful medication primarily used for severe acne that has not responded to other treatments. However, it comes with a range of potential side effects and contraindications, especially concerning liver function and lipid levels.
In your case, your recent blood tests indicate that your ALT level is 52, which is above the normal range (0-40), and your triglycerides are at 251, also above the recommended level (0-150). Elevated liver enzymes and triglycerides can signify underlying health issues, and isotretinoin is known to potentially exacerbate these conditions.
Isotretinoin can affect liver function and lipid metabolism, leading to increased triglyceride levels and liver enzyme elevations. Therefore, it is generally advised that individuals with pre-existing liver dysfunction or hyperlipidemia (high lipid levels) avoid using isotretinoin. The medication can cause further increases in triglycerides and may lead to more significant liver issues, which could be detrimental to your overall health.
Given your current health status, it would be prudent to discuss your situation in detail with your dermatologist or healthcare provider. They may recommend alternative treatments for your acne that do not carry the same risks associated with isotretinoin. Options may include topical treatments, oral antibiotics, or other medications that are safer for individuals with elevated triglycerides and liver enzymes.
Additionally, managing your triglyceride levels through lifestyle changes can be beneficial. This includes adopting a heart-healthy diet low in saturated fats and sugars, increasing physical activity, and maintaining a healthy weight. Regular monitoring of your liver function and lipid levels is also essential, especially if you are considering any new medications.
In summary, given your elevated triglycerides and liver enzyme levels, it is advisable to avoid isotretinoin and seek alternative acne treatments. Always consult with your healthcare provider before starting or stopping any medication, especially when you have existing health concerns. They can provide personalized advice and help you find the safest and most effective treatment for your acne while considering your overall health.
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