Medication Effects and Hypnosis in Mental Health - Psychiatry

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Medication Issues: Hypnotics


Three months ago, after having someone guide me through meditation, I have been experiencing extreme physical discomfort, almost as if I were hypnotized.
Is it convenient for me to contact you regarding this issue? Currently, I take several medications before bed, and recently I added Zoloft (sertraline) 50 mg for a week, totaling seven pills.
Its half-life is approximately 26 hours, so after taking seven pills, I have stopped this medication.
Does it mean I need to wait about 910 hours for it to be almost completely metabolized? Is the drug metabolism and elimination time cumulative? I kindly request your clarification, doctor.

Zhou Yi x, 20~29 year old female. Ask Date: 2016/11/23

Dr. Huang Weiqin reply Psychiatry


Hello: Based on your description of your psychosomatic symptoms and medication issues, it is advisable to first conduct a comprehensive evaluation and discussion with the physician who originally prescribed your medication.
I hope this response is helpful.
Thank you for your inquiry.

Reply Date: 2016/11/23

More Info


Understanding the effects of medication and the role of hypnosis in mental health is a complex topic that requires careful consideration of both pharmacological principles and psychological practices.
Firstly, it is essential to clarify the medication you mentioned, Zoloft (sertraline), which is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for depression, anxiety disorders, and other mental health conditions. The half-life of Zoloft is approximately 26 hours, meaning that it takes about 26 hours for half of the drug to be eliminated from your body. If you have taken seven doses of Zoloft, it is important to understand that the drug does not simply accumulate in your system in a linear fashion. Instead, the concentration of the drug in your bloodstream will peak after a certain period and then gradually decline based on its half-life.

To estimate how long it will take for the drug to be eliminated from your system, you can use the general rule of thumb that it takes about five half-lives for a drug to be considered eliminated from the body. In the case of Zoloft, this would mean approximately 130 hours (or about 5.4 days) after your last dose for the drug to be mostly cleared from your system. However, individual factors such as metabolism, age, liver function, and overall health can influence this timeline.

Regarding your experience of extreme physical discomfort and the sensation of being "hypnotized" after meditation, it is crucial to differentiate between the effects of medication and the psychological effects of meditation or hypnosis. Meditation can sometimes lead to heightened awareness of bodily sensations, which may be interpreted as discomfort or pain, especially if you are already experiencing anxiety or distress. If you feel that your meditation practice is causing you significant discomfort, it may be beneficial to consult with a mental health professional who can help you explore these feelings and determine whether they are related to your medication, your meditation practice, or a combination of both.

Additionally, if you are experiencing adverse effects from your medication, such as increased anxiety or physical pain, it is essential to communicate this with your prescribing physician. They can assess your symptoms, consider potential drug interactions, and adjust your treatment plan accordingly. Stopping or altering medication without professional guidance can lead to withdrawal symptoms or a resurgence of the underlying condition.

In conclusion, understanding medication effects and the impact of practices like meditation requires a holistic approach that considers both the pharmacological aspects and the psychological dimensions of mental health. If you are feeling overwhelmed or confused about your treatment, reaching out to a healthcare provider for personalized advice is always a wise step. They can provide clarity on your medication regimen, help you navigate any side effects, and support you in your mental health journey.

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