the Risks of Infection from Allograft Ligaments in ACL Surgery - Orthopedics

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Risk of allograft ligament infection


I underwent surgery to reconstruct my anterior cruciate ligament (ACL) using an allograft from a donor in early July last year.
I would like to know if there is a risk of contracting diseases such as HIV or hepatitis from using a donated ligament.
Should I get tested? I'm very concerned because I have read literature indicating the possibility of contracting HIV and hepatitis.

Niming, 10~19 year old female. Ask Date: 2017/02/16

Dr. Shi Guozheng reply Orthopedics


Before providing allogeneic materials, they are thoroughly screened to ensure a very low risk of infection.

Reply Date: 2017/02/16

More Info


When considering the risks of infection from allograft ligaments used in ACL (anterior cruciate ligament) reconstruction surgery, it is essential to understand the safety protocols and the inherent risks associated with using donor tissues. Allografts are tissues taken from a deceased donor or a living donor and are processed and sterilized to minimize the risk of transmitting infections.

The concern about potential transmission of diseases such as HIV (Human Immunodeficiency Virus) and hepatitis (both B and C) through allografts is valid, but it is important to note that the risk is extremely low due to stringent screening and processing protocols. In the United States, allograft tissues are regulated by the Food and Drug Administration (FDA) and are subject to rigorous testing for infectious diseases before they are used in surgical procedures. This includes testing for HIV, hepatitis B, and hepatitis C, among other pathogens.

The screening process involves a thorough evaluation of the donor's medical history, as well as laboratory tests to ensure that the tissue is free from infectious agents. Additionally, the processing of allografts typically includes methods such as sterilization and preservation techniques that further reduce the risk of infection.

While the risk of contracting HIV or hepatitis from an allograft is very low, it is not entirely zero. There have been rare cases reported in the literature where infections were transmitted through allografts, but these instances are exceedingly uncommon. The benefits of using allografts, such as improved recovery times and reduced pain compared to autografts (where the patient's own tissue is used), often outweigh the risks.

If you are feeling anxious about the possibility of infection, it is advisable to discuss your concerns with your orthopedic surgeon or healthcare provider. They can provide you with more information about the specific allograft used in your surgery, the screening processes it underwent, and any additional precautions that were taken to ensure its safety. They may also recommend follow-up testing if deemed necessary based on your medical history and any symptoms you may be experiencing.

In summary, while there is a theoretical risk of infection from allograft ligaments in ACL surgery, the actual risk is very low due to rigorous screening and processing protocols. If you have specific concerns or symptoms, it is best to consult with your healthcare provider for personalized advice and reassurance.

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