Endometrial hyperplasia
Hello, doctor.
In September 2017, I was diagnosed with a polyp and underwent polypectomy.
In November 2017, I was found to have endometrial hyperplasia, and the doctor prescribed progesterone (Medroxyprogesterone 5 mg) with the label 131, indicating it is a Category X medication.
I was instructed to take it for three months.
After completing the third month of medication, I discovered that I am pregnant.
I am unsure if I can keep this baby.
Will the medication affect the fetus? Does my current pregnancy indicate that my endometrial thickness is normal?
Xiao Mei, 30~39 year old female. Ask Date: 2017/03/05
Dr. Huang Jianzhong reply Obstetrics and Gynecology
In September 2017, a polyp was discovered, and after a polypectomy, endometrial hyperplasia was found in November 2017.
The physician prescribed progesterone (Medroxyprogesterone 5 mg) with the imprint 131, indicating it is a Category X medication, and advised me to take it for three months.
After completing the third month of medication, I discovered that I am pregnant.
I am unsure if I can continue with this pregnancy and whether the medication will affect the fetus.
Does my current pregnancy indicate that my endometrial thickness is normal? Answer: Please visit a medical center for a detailed examination and medication consultation.
Reply Date: 2017/03/05
More Info
Endometrial hyperplasia is a condition characterized by the thickening of the endometrial lining of the uterus, often due to an imbalance in hormonal levels, particularly an excess of estrogen without sufficient progesterone. This condition can lead to abnormal uterine bleeding and, in some cases, may increase the risk of developing endometrial cancer if left untreated.
In your case, after the removal of a polyp, you were prescribed a medication containing progesterone (美得能, or Medroxyprogesterone) to help regulate your menstrual cycle and address the hyperplasia. The classification of this medication as an "X" category drug indicates that it may pose risks during pregnancy, particularly in the first trimester. However, it is essential to understand that the classification does not automatically mean that the medication will cause harm; rather, it suggests that there is a potential risk based on animal studies or limited human data.
Regarding your pregnancy, it is crucial to consult with your healthcare provider to assess the situation thoroughly. The fact that you have become pregnant after taking the medication does not necessarily indicate that your endometrial thickness is normal; rather, it suggests that the hormonal treatment may have been effective in promoting a suitable environment for implantation.
The primary concern with taking progesterone during early pregnancy is its potential effects on fetal development. Generally, progesterone is crucial for maintaining pregnancy, as it helps to stabilize the uterine lining and prevent contractions. In many cases, healthcare providers prescribe progesterone to women with a history of miscarriage or those experiencing bleeding in early pregnancy to support the pregnancy.
However, since you are aware of the medication's classification, it is essential to have a detailed discussion with your doctor about the risks and benefits. They may recommend monitoring your pregnancy closely, including ultrasounds and blood tests, to ensure that both you and your baby are healthy.
If you are concerned about the effects of the medication on your fetus, your doctor may suggest additional tests or evaluations to assess fetal development and well-being. It is also important to discuss any symptoms you may be experiencing, such as bleeding or cramping, as these can be indicators of complications that may require immediate attention.
In summary, while there are potential risks associated with taking progesterone during pregnancy, it is also a critical hormone for maintaining a healthy pregnancy. Your healthcare provider will be the best resource for navigating these concerns, as they can provide personalized advice based on your medical history and current condition. It is vital to maintain open communication with your healthcare team and follow their recommendations for monitoring and managing your pregnancy effectively.
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