Abnormal Findings in Nasal Endoscopy: Is It Nasopharyngeal Cancer? - Otolaryngology

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Abnormal findings on nasal endoscopy?


Hello Dr.
Zheng, I would like to ask about my father, who is a liver cancer patient.
He underwent a second surgery about six months ago, and his liver function tests are all normal.
However, after the surgery, he has been experiencing middle ear effusion and throat pain.
The primary surgeon mentioned that it could be due to anesthesia entering the ear and suggested a minor ear surgery to drain the fluid.
Before the surgery, he had an endoscopic examination by an ENT specialist, who indicated that there is a possibility of nasopharyngeal cancer.
They ordered a blood test but did not perform a biopsy.
I would like to inquire if the presence of abnormalities found during the endoscopy significantly increases the likelihood of nasopharyngeal cancer.
Thank you.

Chris, 30~39 year old female. Ask Date: 2017/04/07

Dr. Zheng Jueyi reply Otolaryngology


Hello: To confirm nasopharyngeal carcinoma, a biopsy is still necessary.
Blood tests can provide some reference, but if the blood results are abnormal, a biopsy is still recommended for diagnosis.
Wishing you safety and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2017/04/07

More Info


When it comes to abnormal findings in nasal endoscopy, particularly in the context of potential nasopharyngeal cancer (NPC), it is crucial to understand the limitations and capabilities of the diagnostic tools available. Nasal endoscopy is a valuable procedure that allows physicians to visualize the nasal passages and nasopharynx directly. However, while it can reveal abnormalities such as masses, lesions, or other structural changes, it cannot definitively diagnose cancer without further testing, such as a biopsy.

In your father's case, the presence of abnormal findings during the nasal endoscopy raises concerns that warrant further investigation. However, it is essential to note that not all abnormalities detected in the nasopharynx are indicative of cancer. Conditions such as benign tumors, infections, or inflammatory processes can also present with similar findings. Therefore, while the endoscopic examination can suggest the possibility of nasopharyngeal cancer, it is not conclusive.

The next step typically involves obtaining a biopsy of any suspicious lesions observed during the endoscopy. A biopsy is the gold standard for diagnosing cancer, as it allows for histopathological examination of the tissue. Blood tests, such as those for tumor markers or viral infections (like Epstein-Barr virus, which is associated with NPC), can provide additional context but are not definitive on their own.

In your father's situation, given his history of liver cancer and the recent symptoms of ear fluid accumulation and throat pain, it is understandable to be concerned about the possibility of nasopharyngeal cancer. However, it is important to approach this situation with a balanced perspective. The fact that a biopsy has not yet been performed means that a definitive diagnosis has not been established. The physician's recommendation for blood tests is a prudent step, but it should not replace the need for a biopsy if there are concerning findings.

If the endoscopy revealed abnormalities, it is advisable to follow up with the healthcare provider to discuss the necessity of a biopsy. This discussion should include the potential risks and benefits of the procedure, as well as any alternative diagnostic options that may be available. It is also important to consider the overall clinical picture, including any other symptoms your father may be experiencing, his medical history, and the results of any imaging studies that may have been conducted.

In summary, while nasal endoscopy can identify abnormalities that may suggest nasopharyngeal cancer, it is not a definitive diagnostic tool. A biopsy is essential for confirming or ruling out cancer. Given your father's medical history and current symptoms, it is crucial to maintain open communication with his healthcare team to ensure that appropriate follow-up actions are taken. Early diagnosis and intervention can significantly impact treatment outcomes, so addressing any concerns promptly is vital for your father's health and peace of mind.

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