Liver Function Tests: AST, ALT, and hsCRP Levels Explained

Liver function tests (LFTs)

AST test result: 19
ALT test result: 48
hsCRP test result: 1.50
On 4/20:
AST test result: 20
ALT test result: 47
hsCRP test result: 1.24
The patient is currently receiving intravenous antibiotics (Vesicant) for the treatment of osteomyelitis.
Is this considered a normal phenomenon? Thank you very much for your response, doctor.

Wenzi, 30~39 year old female. Ask Date: 2017/05/05

Dr. Chen Shidian reply Gastroenterology and Hepatology

Hello, the changes in your liver function indices are minimal.
As long as the liver ultrasound is normal and there are no hepatitis B or C infections, you can continue with regular monitoring.
Changhua Hospital cares about your health.
Chen Shidian

Reply Date: 2017/05/05

More Info

Understanding liver function tests is crucial for assessing liver health and identifying potential issues. In your case, you have provided values for AST (aspartate aminotransferase), ALT (alanine aminotransferase), and hsCRP (high-sensitivity C-reactive protein). Let's break down what these values mean, especially in the context of your ongoing treatment for osteomyelitis with antibiotics.

AST and ALT Levels
1. AST (19-20): Your AST levels are within the normal range (typically 10-40 U/L), indicating that there is no significant liver damage or dysfunction related to this enzyme. AST is found in various tissues, including the liver, heart, and muscles, so elevated levels can indicate issues beyond just liver health.

2. ALT (48-47): Your ALT levels are slightly elevated (normal range is typically 7-56 U/L). ALT is more specific to the liver than AST, so an elevated ALT can suggest liver cell injury. However, your values are not excessively high, which is a positive sign.

hsCRP Levels
3. hsCRP (1.50 and 1.24): hsCRP is a marker of inflammation in the body. Normal levels are generally below 1.0 mg/L, while levels between 1.0 and 3.0 mg/L indicate a moderate risk of cardiovascular disease. Your values suggest mild inflammation, which could be related to your current infection (osteomyelitis) or other factors.

Context of Antibiotic Treatment
Given that you are currently receiving intravenous antibiotics for osteomyelitis, it is important to consider how this treatment might affect your liver function tests. Some antibiotics can cause transient elevations in liver enzymes, but this is usually not a cause for concern unless the levels become significantly elevated or are accompanied by symptoms such as jaundice, abdominal pain, or severe fatigue.

Recommendations
1. Monitoring: Continue to monitor your liver function tests as part of your treatment plan. It is essential to keep your healthcare provider informed about any changes in your symptoms or overall health.

2. Follow-Up Testing: After completing your antibiotic treatment, it may be beneficial to repeat liver function tests to ensure that your liver enzymes return to baseline levels.

3. Lifestyle Considerations: Maintain a healthy lifestyle to support liver health. This includes avoiding alcohol, eating a balanced diet rich in fruits and vegetables, and staying hydrated.

4. Consult Your Doctor: If you have concerns about your liver function tests or the effects of your antibiotic treatment, discuss them with your healthcare provider. They can provide personalized advice and may consider additional testing if necessary.

Conclusion
In summary, your AST levels are normal, while your ALT levels are slightly elevated, which could be a result of your current antibiotic treatment or other factors. Your hsCRP levels indicate mild inflammation, likely related to your ongoing infection. Regular monitoring and communication with your healthcare provider will be key in managing your liver health during this treatment period.

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