Panic Disorder: Medication Changes and Withdrawal Symptoms - Psychiatry

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Anxiety Panic Disorder


Hello, Doctor.
I have some questions I would like to ask you.
Since I had an episode of hyperventilation after a meal during a business trip last July, I experienced another episode of hyperventilation in October that made me feel scared, and I was later diagnosed with panic disorder.
I was originally seeing a doctor at a small clinic, where I was prescribed Propranolol HCl, Fuanyuan tablets, and JEXIT S.C.
The regimen was to take Propranolol and Fuanyuan three times a day, and two JEXIT tablets before bedtime.
I usually follow this regimen, but when panic symptoms suddenly occur, I would take Anpaning.
Recently, I switched to a new clinic, where I explained how I was taking my previous medications.
The new doctor prescribed Lexapro, Entalapram tablets, and Xanax.
The new regimen is to take Entalapram and Xanax only when symptoms occur, with Lexapro taken after meals.

I would like to ask if I am experiencing withdrawal symptoms, as my condition has not been very good in the past week or two.
I often feel my face getting warm, sweating, and my heart racing, with a sense of impending panic.
Additionally, after taking Xanax, I sometimes experience anxiety again 2 to 3 hours later, and I am unsure if I should take another Xanax.
I am still in the process of adjusting my medication with my doctor, but I have been feeling quite uncomfortable lately, with frequent episodes.
Therefore, I would like to ask if I am experiencing withdrawal symptoms, and whether Xanax should be taken at fixed times to maintain its therapeutic level, or if it is still appropriate to take it only when symptoms arise, as I did before.
Thank you, Doctor.

Wen, 20~29 year old female. Ask Date: 2017/05/24

Dr. Dai Wanxiang reply Psychiatry


Hello, Mr.
Wen: Based on your description, the symptoms that appeared after changing medication could indeed be withdrawal symptoms.
However, it is essential to discuss this with your treating physician to determine the best pharmacological treatment approach.
Xanax is an effective anxiolytic medication, and whether it is taken at fixed times or as needed varies depending on each individual's diagnosis, frequency of symptoms, and severity.
However, if benzodiazepines (such as Xanax and Klonopin) are used long-term, it is generally recommended to taper the dosage gradually or consider alternative medications to avoid withdrawal symptoms.
Wishing you well.

Reply Date: 2017/05/24

More Info


Panic disorder can be a challenging condition to manage, especially when it involves medication changes and potential withdrawal symptoms. It seems that you have been navigating through a complex treatment regimen, and your concerns about the recent changes in your medication are valid.
Firstly, it's important to understand that when switching medications, especially in the context of treating panic disorder, your body may react in various ways. The symptoms you are experiencing—such as facial flushing, sweating, increased heart rate, and feelings of impending panic—could indeed be indicative of withdrawal symptoms from the medications you were previously taking, particularly if those medications were abruptly discontinued or if the new medications are not yet fully effective.

Propranolol, which you were previously taking, is a beta-blocker that can help manage physical symptoms of anxiety, such as rapid heartbeat and sweating. If you stopped taking it suddenly, your body might be reacting to the absence of its calming effects. Similarly, the medications you are now prescribed, including Lexapro (an SSRI), Entacapone, and Xanax (a benzodiazepine), have different mechanisms of action and may take time to stabilize in your system. Lexapro, for instance, typically takes several weeks to reach its full therapeutic effect, and during this adjustment period, you may experience fluctuations in anxiety levels.

Regarding Xanax, it is crucial to follow your doctor's instructions on how to take it. Xanax is often prescribed for acute anxiety episodes, and while it can be taken as needed, it is generally recommended to use it sparingly to avoid dependence. If your doctor has advised you to take it only when symptoms arise, then you should continue to do so. However, if you find that you are needing to take it more frequently than prescribed, or if your anxiety is not improving, it is essential to communicate this with your healthcare provider.

In terms of managing withdrawal symptoms, it is advisable to maintain open communication with your doctor. They may consider adjusting your medication regimen or providing additional support during this transition period. It is also worth noting that some individuals may experience heightened anxiety when changing medications, which can create a cycle of fear and panic. Engaging in relaxation techniques, mindfulness practices, or cognitive-behavioral strategies can be beneficial in managing these feelings.

Lastly, if you feel that your symptoms are worsening or becoming unmanageable, do not hesitate to seek immediate medical attention. Your mental health is paramount, and it is essential to ensure that you are receiving the appropriate care and support during this time.
In summary, the symptoms you are experiencing could be related to medication changes and potential withdrawal effects. It is crucial to discuss these concerns with your healthcare provider to ensure that you receive the best possible treatment for your panic disorder. Regular follow-ups and adjustments to your medication may be necessary to find the right balance for your mental health.

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