Unexpected Growth of Liver Hemangioma: A Yearly Follow-Up Concern - Gastroenterology and Hepatology

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A continuously monitored hemangioma suddenly increased in size by three centimeters within one year?


Three years ago, during a health check-up, two tumors were found in the liver.
A subsequent CT scan confirmed that both were hemangiomas, with one measuring approximately three centimeters.
Since then, I have been undergoing regular follow-ups every six months, including blood tests and ultrasounds.
Last year, during my pregnancy, it was discovered that the hemangioma had grown to four centimeters, and at the same time, my AFP report showed abnormally high levels.
The doctor mentioned that this was likely due to pregnancy-related fetal protein abnormalities and recommended follow-up after delivery.
Today, during my follow-up appointment, an ultrasound revealed that the hemangioma had grown to seven centimeters (four months postpartum).
The doctor immediately arranged for an MRI and blood tests.
However, research indicates that hemangiomas typically do not grow significantly or transform into liver cancer.
Why has it suddenly increased by three centimeters in less than a year? Could it be something more serious?

Hong Ka Fei, 30~39 year old female. Ask Date: 2017/06/15

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello Ms.
Hong, very few hemangiomas will enlarge.
Please continue to monitor and consider excision or other treatments if necessary.
Changhua Hospital cares about your health.
Chen Shidian

Reply Date: 2017/06/15

More Info


Liver hemangiomas are benign vascular tumors that are generally asymptomatic and often discovered incidentally during imaging studies. The growth of a hemangioma, particularly one that has increased in size from 3 cm to 7 cm in less than a year, can understandably raise concerns. However, it is important to contextualize this growth within the characteristics of hemangiomas and the factors that may influence their behavior.

Firstly, hemangiomas are typically classified as benign lesions, and the vast majority do not undergo malignant transformation. They are composed of a mass of blood vessels and can vary in size. While it is true that many hemangiomas remain stable or even shrink over time, some can grow, particularly in response to hormonal changes, such as those that occur during pregnancy. The increase in size you observed during your pregnancy may be attributed to the elevated levels of estrogen and other hormones, which can stimulate the growth of vascular lesions.

The fact that your AFP (alpha-fetoprotein) levels were elevated during pregnancy is also noteworthy. AFP is a protein that can be produced by the liver and is often elevated in certain liver conditions, including hepatocellular carcinoma. However, during pregnancy, elevated AFP levels can also be a normal physiological response due to the developing fetus. Your doctor’s suggestion to monitor the hemangioma post-pregnancy is prudent, as the hormonal influences may subside, potentially stabilizing the hemangioma.

Regarding the rapid growth of your hemangioma from 4 cm to 7 cm in just a few months, this is indeed unusual for a hemangioma. While most hemangiomas grow slowly, some can exhibit more rapid growth, particularly in specific contexts such as pregnancy. It is essential to follow up with the MRI and blood tests as recommended by your physician. These tests will provide more detailed information about the hemangioma's characteristics and help rule out any other potential issues.

In terms of management, if the MRI confirms that the lesion is indeed a hemangioma and there are no signs of malignancy, the standard approach is often continued observation. Surgical intervention is typically reserved for cases where the hemangioma is symptomatic (causing pain or other issues) or if there is uncertainty about the diagnosis.
In conclusion, while the growth of your liver hemangioma is concerning, it is essential to remember that hemangiomas are usually benign. The hormonal changes associated with pregnancy may have contributed to the rapid increase in size. It is crucial to adhere to your follow-up appointments and diagnostic tests to ensure proper monitoring and management. If you have any further concerns or if symptoms arise, do not hesitate to discuss them with your healthcare provider. Regular monitoring and open communication with your medical team are key to managing your health effectively.

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