Urine Test Results: Microalbumin and Kidney Function Explained - Urology

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Hello, Doctor.
Last month, I had a health check-up, and there were a few issues with my urine test that I would like to discuss.
Below are the highlighted results: microalbumin 36.51 and glomerular filtration rate (GFR) 91.56.
Could you please evaluate whether these values are significantly above the normal range? What types of conditions could lead to abnormal values? Can microalbumin levels fluctuate, showing a sudden increase and then a decrease shortly after? I am 30 years old and have a light diet, although I don't drink much water.
My family does not have diabetes, but I have heard that elevated microalbumin levels can be caused by diabetes.
Additionally, my blood sugar report shows fasting blood sugar at 92, oral glucose tolerance test at 93, and hemoglobin A1c at 5.2.
Are these values within the normal range? Thank you, Doctor.

Hsun, 30~39 year old female. Ask Date: 2017/06/21

Dr. Du Shixi reply Urology


Hello: Everything is fine.
As for proteinuria in urine, it can vary depending on the body's condition (diet, exercise, etc.), so one instance should be taken as a reference.
Wishing you good health.

Reply Date: 2017/06/21

More Info


Understanding urine test results, particularly regarding microalbumin and kidney function, is crucial for assessing renal health. In your case, the reported values of microalbumin at 36.51 mg/dL and an estimated glomerular filtration rate (eGFR) of 91.56 mL/min provide important insights into your kidney function.


Microalbumin and Its Significance
Microalbuminuria refers to the presence of a small amount of albumin in the urine, which is an early sign of kidney damage, particularly in individuals with risk factors such as diabetes or hypertension. The normal range for microalbumin in urine is typically less than 30 mg/dL. Values between 30 to 300 mg/dL indicate microalbuminuria, while values above 300 mg/dL suggest macroalbuminuria, which is a more advanced stage of kidney disease.

In your case, a microalbumin level of 36.51 mg/dL indicates that you are in the microalbuminuria range. This suggests that there may be some degree of kidney damage or dysfunction. However, it is essential to consider this result in the context of other factors, including your overall health, family history, and lifestyle.


eGFR and Kidney Function
The eGFR of 91.56 mL/min is within the normal range, which typically is above 90 mL/min for healthy adults. This indicates that your kidneys are still functioning well in terms of filtering waste from the blood. However, the presence of microalbuminuria, despite a normal eGFR, can be a warning sign that should not be overlooked.


Possible Causes of Elevated Microalbumin
Several factors can contribute to elevated microalbumin levels, including:
1. Diabetes: While you mentioned that there is no family history of diabetes, it is important to monitor blood sugar levels regularly. Your fasting blood sugar of 92 mg/dL, oral glucose tolerance test result of 93 mg/dL, and hemoglobin A1c of 5.2% are all within normal limits, suggesting that you are not currently diabetic.

2. Hypertension: High blood pressure can damage the kidneys over time. If you have a history of hypertension, this could be a contributing factor.

3. Dehydration: Since you mentioned that you do not drink much water, dehydration can concentrate urine and potentially lead to higher levels of microalbumin. It is advisable to maintain adequate hydration.

4. Physical Stress: Intense physical activity or stress can temporarily elevate microalbumin levels.

5. Infections or Inflammation: Urinary tract infections or other inflammatory conditions can also cause transient increases in microalbumin.


Fluctuations in Microalbumin Levels
Microalbumin levels can indeed fluctuate due to various factors, including hydration status, physical activity, and acute illness. It is not uncommon for individuals to have varying results upon repeated testing. Therefore, it is essential to monitor these levels over time to assess any trends.


Recommendations
1. Follow-Up Testing: It is advisable to repeat the urine test to confirm the microalbumin level, ideally under similar conditions (hydration status, time of day, etc.).

2. Lifestyle Modifications: Maintain a balanced diet, stay hydrated, and engage in regular physical activity. These changes can help improve overall kidney health.

3. Regular Monitoring: Keep track of your kidney function and blood sugar levels, especially if you have risk factors for diabetes or hypertension.

4. Consult a Specialist: If microalbumin levels remain elevated, consider consulting a nephrologist for further evaluation and management.

In conclusion, while your eGFR is normal, the elevated microalbumin level warrants attention. It is essential to monitor your kidney health and make lifestyle adjustments as needed. Regular follow-ups with your healthcare provider will help ensure that any potential issues are addressed promptly.

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