Assessing Low Risk and Medication Timing in PEP Treatment - Internal Medicine

More Info

---

When it comes to Post-Exposure Prophylaxis (PEP) treatment, understanding the timing of medication and the associated risks is crucial. In your case, you were assessed by a physician who determined that your risk of HIV transmission from the oral sexual encounter was low, which is consistent with current medical understanding. Oral sex, particularly when there are no visible wounds or bleeding, generally poses a lower risk for HIV transmission compared to anal or vaginal intercourse. However, it is important to remember that no sexual activity is completely without risk.

You began your PEP regimen with Cabotegravir (Cabenuva), taking your first dose within 45 hours of potential exposure. The timing of starting PEP is critical; it is most effective when initiated as soon as possible after potential exposure, ideally within 72 hours. Since you started within this window, you have maximized your chances of preventing HIV infection.

Regarding your question about the 40-minute delay in taking your medication, it is generally recommended to take PEP medications at the same time each day to maintain consistent drug levels in your bloodstream. However, a delay of 40 minutes is not likely to significantly impact the overall effectiveness of the medication. Most antiretroviral medications, including those used in PEP, have a relatively long half-life, meaning they remain effective in your system for a period of time even if taken slightly later than scheduled.
That said, consistency is key. Regularly taking your medication at the same time each day helps to maintain steady drug levels, which is important for maximizing efficacy and minimizing the risk of developing drug resistance. If you find that you are frequently unable to take your medication on time, it may be helpful to set reminders or find a routine that works better for you.

In summary, your risk from the exposure you described is considered low, and starting PEP promptly was a wise decision. A 40-minute delay in taking your medication is unlikely to have a significant impact on its effectiveness, but it is important to strive for consistency in your dosing schedule. If you have any further concerns or experience any side effects, do not hesitate to reach out to your healthcare provider for guidance. They can provide you with the best advice tailored to your specific situation and help you navigate any uncertainties you may have regarding your treatment.