Assessing HIV Risk After Mutual Masturbation and PEP Treatment - Urology

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HIV/AIDS issues


Engaging in sexual activity with a stranger, during foreplay we touched each other's genitals without any kissing.
She also assisted me with masturbation (her vaginal secretions dripped onto my genitals).
Due to concerns, we did not engage in any sexual activity beyond mutual masturbation.
I took the first dose of PEP medication within six hours and continued to take it for a full 28 days.
I would like to ask the doctor, what is my risk of contracting HIV at this point? Additionally, I would like to know if missing a single dose of the PEP medication would affect the overall treatment regimen.

Songxia Ri, 20~29 year old female. Ask Date: 2024/05/05

Dr. Du Shixi reply Urology


Hello: It is advisable to consult the prescribing physician, as the risks can be significantly reduced.
According to health data, if medications are taken correctly, Post-Exposure Prophylaxis (PEP) can effectively prevent HIV infection, although it is not 100% effective.
Research indicates that PEP can effectively prevent 81% of HIV infections in cases of occupational exposure.
In situations involving sexual contact with the HIV virus, PEP can effectively prevent over 99% of HIV infections.
There is a possibility of PEP treatment failure, and patients should undergo an HIV antibody test three months after completing the regimen to confirm that they have not contracted HIV.

Reply Date: 2024/05/05

More Info


When assessing the risk of HIV infection after engaging in mutual masturbation, it is important to understand the nature of the activities involved and the timing of post-exposure prophylaxis (PEP) treatment. Mutual masturbation, where both partners stimulate each other's genitals, generally poses a lower risk for HIV transmission compared to penetrative sexual activities. However, there are still some factors to consider.

In your case, you mentioned that there was no kissing and that the only contact involved was mutual masturbation. The concern arises from the fact that the female partner's vaginal secretions came into contact with your genital area. While the risk of HIV transmission through this type of contact is significantly lower than through unprotected intercourse, it is not entirely negligible, especially if there are cuts or abrasions on the skin.

You took your first dose of PEP within six hours of the potential exposure, which is excellent, as PEP is most effective when started as soon as possible after potential exposure to HIV. The standard PEP regimen typically lasts for 28 days, and adherence to the medication is crucial for it to be effective. If you completed the full 28-day course of PEP, your risk of contracting HIV is significantly reduced. Studies have shown that when PEP is taken correctly, it can reduce the risk of HIV infection by up to 80% or more.

Regarding your question about the impact of missing a single dose of PEP, it is important to understand that while missing one dose may not completely negate the effectiveness of the treatment, it can potentially lower the overall efficacy. The key to PEP is consistent and correct usage. If you missed a dose, it is advisable to take it as soon as you remember, and then continue with your regular dosing schedule. If you have concerns about missing a dose or the effectiveness of your PEP treatment, it would be wise to consult with your healthcare provider for personalized advice.

In summary, while there is a risk associated with any sexual activity, the risk of HIV transmission from mutual masturbation is relatively low, especially given that you initiated PEP treatment promptly. Completing the full course of PEP is crucial, and while missing a single dose is not ideal, it does not necessarily mean that the treatment will fail. Regular follow-up testing is recommended to ensure that you remain HIV-negative, and it is generally advised to wait at least three months after potential exposure for conclusive testing. If you have any further concerns or symptoms, please consult your healthcare provider for guidance.

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