Assessing HIV and Syphilis Risk After Unprotected Oral Sex: A Patient's Journey - Urology

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Post-exposure testing for RT-PCR and combo tests after unprotected receptive oral sex?


Hello Doctor, on September 5th, I had unprotected oral sex for about 1-2 minutes without ejaculation.
After 25 days, I underwent a fourth-generation rapid test for syphilis and HIV, and the result was negative.
However, I was still concerned, so on October 3rd, 28 days later, I took an ELISA fourth-generation antibody and antigen test, as well as an RT-PCR test, both of which were negative and did not detect any RNA.
Can I currently rule out HIV and syphilis infection? I have read articles about elite controllers and am very worried about the possibility of seroconversion.
I also saw some articles from Chang Gung Memorial Hospital stating that the window period is about 3-4 weeks, but foreign sources say that the ELISA test has only a 95% accuracy rate at 4 weeks.
Recently, I have been feeling a bit dizzy and have lost my appetite, possibly due to stress.
Although websites like Heart of the Valley, ADISMAP, and MedHelp state that passive oral sex is low risk, even theoretical risk, I am still very anxious.
I will definitely avoid such places in the future, and I plan to get a final test after 84 days, but I still have psychological shadows lingering.
Thank you for your help!

MATT, 20~29 year old female. Ask Date: 2018/10/11

Dr. Du Shixi reply Urology


Hello: The official information on HIV indicates that the window period is 6 to 12 weeks for conclusive results.
As for risk levels: No risk - masturbation; Low risk - mutual masturbation, light kissing, mutual rubbing, sexual activity with condom use; Moderate risk - deep kissing, oral sex, withdrawal method; High risk - unprotected sexual activity that causes wounds or bleeding.
You can refer to the following links for more information.

Reply Date: 2018/10/11

More Info


Assessing the risk of HIV and syphilis after engaging in unprotected oral sex can be a source of significant anxiety for many individuals. In your case, you mentioned having unprotected oral sex with a sex worker on September 5th, and subsequently undergoing multiple tests for HIV and syphilis, all of which returned negative results. It’s understandable that you are feeling anxious, especially given the conflicting information available regarding the window period for HIV testing and the risk associated with oral sex.

First, let’s clarify the risk factors involved. Oral sex is generally considered to be a lower-risk activity for HIV transmission compared to vaginal or anal intercourse. However, it is not without risk, particularly if there are cuts or sores in the mouth, or if the partner is HIV positive and has a high viral load. In your case, since you did not ejaculate during the encounter and have tested negative for HIV using both the fourth-generation antigen/antibody test and RT-PCR, the likelihood of having contracted HIV is very low. The fourth-generation tests are quite reliable, and a negative result at 28 days post-exposure is reassuring.
Regarding syphilis, the risk of transmission through oral sex is also present, but it is generally lower than that of other sexually transmitted infections (STIs). If you have tested negative for syphilis, it is a good indication that you have not contracted the infection. However, it is important to consider that syphilis can sometimes be asymptomatic, so if you have any concerns, follow-up testing is advisable.

The window period for HIV testing can vary depending on the type of test used. For fourth-generation tests, the majority of infections can be detected within 28 days, but it is recommended to have a follow-up test at three months for conclusive results. This is because while the sensitivity of these tests is high, there is still a small chance of a false negative result during the early stages of infection.

Your feelings of anxiety and physical symptoms such as dizziness and loss of appetite are not uncommon in situations like this. The psychological impact of potential exposure to STIs can be significant, and it’s important to address these feelings. Here are some strategies to help manage your anxiety:
1. Educate Yourself: Understanding the actual risks associated with your sexual behavior can help alleviate fears. Reliable sources include the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO).

2. Seek Support: Talking to a healthcare professional about your concerns can provide reassurance and guidance. Additionally, consider reaching out to friends or support groups who can provide emotional support.

3. Practice Self-Care: Engage in activities that promote relaxation and well-being, such as exercise, meditation, or hobbies that you enjoy. Maintaining a healthy lifestyle can also help improve your mood and reduce anxiety.

4. Follow-Up Testing: As you mentioned, planning to get tested again at 84 days is a good idea. This will provide you with further peace of mind.
5. Limit Exposure to Stressors: If reading about HIV and STIs online increases your anxiety, consider taking a break from such information until you feel more grounded.

In conclusion, based on the information provided and your negative test results, it is likely that you have not contracted HIV or syphilis. However, continuing to monitor your health and seeking further testing as needed is wise. Remember, it’s essential to prioritize your mental health and seek help if your anxiety becomes overwhelming.

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