Managing Recurrent Urinary Tract Infections: D-Mannose and Beyond - Urology

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Urinary tract issues


Hello, doctor.
I am a 30-year-old female and I experience urinary tract infections several times a year.
Each time I visit the doctor, the only option I receive is antibiotics, but I really don't want to keep taking them as I am concerned about developing antibiotic resistance over time.
Recently, I discovered D-Mannose, which can help eliminate most E.
coli bacteria, so I tried it for about a week and noticed an improvement.
My urine output is normal, and I no longer have pain while urinating.
However, I have noticed that sometimes the first urine in the morning has a strong odor (without any other discomfort).
When I take D-Mannose, the odor improves and gradually disappears.
Although I am currently on my menstrual period, I have not experienced this strong urine odor in the past.
What should I do about this? (Since I am not experiencing any discomfort, just the odor.) I would appreciate your advice, thank you.
Additionally, last week I had a cold and one night I suddenly felt chills.
I thought it might be due to the cold and didn't pay much attention to it.
The next day, I visited my family doctor, who mentioned that the chills, weakness, and fatigue could be related to a urinary tract infection.
However, I felt completely recovered the following day.
I am concerned that even though it has passed, I am unsure whether it was due to the cold or a urinary tract infection, and whether it could have harmed my kidneys.
Should I get checked?

jennifer, 30~39 year old female. Ask Date: 2017/09/08

Dr. Du Shixi reply Urology


Hello: If it is cystitis, there is usually no fever or chills; however, pyelonephritis is more likely to cause fever and chills.
It is recommended to perform a urinalysis for safety.

Reply Date: 2017/09/08

More Info


Managing recurrent urinary tract infections (UTIs) can be a challenging issue, especially for women who experience them frequently. Your concerns about antibiotic resistance are valid, as overuse of antibiotics can lead to resistant strains of bacteria, making future infections harder to treat. D-Mannose, a simple sugar, has gained attention as a potential alternative for preventing and managing UTIs, particularly those caused by E. coli, the most common pathogen involved in these infections.

D-Mannose works by adhering to the E. coli bacteria in the urinary tract, preventing them from attaching to the bladder wall and facilitating their removal through urination. Some studies suggest that D-Mannose can be effective in reducing the recurrence of UTIs, and many patients report positive outcomes, as you have experienced. However, it is important to note that while D-Mannose may help with prevention, it is not a substitute for antibiotics in cases of active infections. If you are currently symptom-free but notice a change in the odor of your urine, this could be due to several factors, including dietary changes, dehydration, or the presence of certain bacteria. The fact that the odor improves with D-Mannose suggests that it may be helping to flush out bacteria, but it is essential to monitor your symptoms closely.

Regarding your concern about whether a previous cold or UTI could have caused kidney damage, it is generally unlikely that a mild UTI would lead to significant kidney issues if treated promptly. However, if you experience symptoms such as fever, chills, flank pain, or persistent changes in urination, it would be wise to consult a healthcare provider for further evaluation. A urinalysis or urine culture can help determine if there is an ongoing infection that requires treatment.

In addition to D-Mannose, there are several other strategies you can consider to help manage recurrent UTIs:
1. Hydration: Drinking plenty of water can help dilute your urine and flush out bacteria from your urinary tract.

2. Cranberry Products: While the evidence is mixed, some studies suggest that cranberry juice or supplements may help prevent UTIs by preventing bacteria from adhering to the bladder wall.

3. Probiotics: Some research indicates that probiotics may help maintain a healthy balance of bacteria in the urinary tract and reduce the risk of infections.

4. Hygiene Practices: Proper hygiene, such as wiping from front to back and urinating after sexual intercourse, can help reduce the risk of UTIs.

5. Avoiding Irritants: Certain products, such as douches, scented soaps, and bubble baths, can irritate the urinary tract and increase the risk of infections.

6. Consulting a Specialist: If UTIs continue to recur despite these measures, it may be beneficial to consult a urologist or a specialist in infectious diseases for further evaluation and management options.

In summary, while D-Mannose appears to be a promising adjunct in managing recurrent UTIs, it is essential to maintain a comprehensive approach that includes hydration, hygiene, and possibly other preventive measures. If you have any ongoing concerns or symptoms, do not hesitate to seek medical advice to ensure your urinary health is properly managed.

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