Can Pregnant Women Safely Take Antihistamines for Hives? - Obstetrics and Gynecology

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Can pregnant women take antihistamines for urticaria?


Hello Doctor, I am currently 30 years old and 9 weeks pregnant.
I have a history of allergies since childhood; I had urticaria in middle school, and my eczema has not completely healed.
However, I have managed it well with traditional Chinese medicine and dietary control, so it hasn't been a major issue.
Recently, I am unsure if it's due to hormonal changes from pregnancy or if I've consumed foods that are prone to causing allergies, such as kiwi (which I had never been allergic to before), leading to urticaria.
I visited a dermatologist, who prescribed an antihistamine, "SOMIN TABLETS 2MG (DEXCHLORPHENIRAMINE)." Although the doctor mentioned that this medication is classified as Category B and can be taken three times a day, I am still concerned about its potential impact on my child's development.
I only take one tablet a day at most.
I would like to consult a professional obstetrician regarding whether I should continue taking this medication.
Thank you.

Danxin de yun mami, 30~39 year old female. Ask Date: 2017/09/13

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I am 9 weeks pregnant and have a history of allergic conditions.
In middle school, I experienced urticaria, and I have not fully recovered from eczema, but I have managed it well with traditional Chinese medicine and dietary control, so it hasn't been a major issue.
Recently, I am unsure if it is due to hormonal changes from pregnancy or if I consumed kiwi and other allergenic foods (I had never been allergic to kiwi before), which triggered urticaria.
I consulted a dermatologist, who prescribed "SOMIN TABLETS 2MG (DEXCHLORPHENIRAMINE)." Although the doctor mentioned that this medication is classified as Category B and can be taken three times a day, I am still concerned about its impact on my child's development.
I limit myself to one tablet a day and would like to consult a professional obstetrician about whether I should continue taking this medication.
Answer: This medication is Category B, and it is safe to continue taking it.

Reply Date: 2017/09/13

More Info


When it comes to the use of antihistamines during pregnancy, particularly for conditions like hives, it is essential to consider both the safety of the medication and the potential risks to the developing fetus. In your case, you have been prescribed Dexchlorpheniramine (Somin Tablets), which is classified as a Category B medication by the FDA. This classification indicates that animal studies have not demonstrated any risk to the fetus, although there are no well-controlled studies in pregnant women.

Antihistamines, including Dexchlorpheniramine, are commonly used to alleviate allergic reactions, including hives. They work by blocking the action of histamine, a substance in the body that causes allergic symptoms. While many antihistamines are considered safe during pregnancy, it is crucial to use them judiciously and under the guidance of a healthcare provider.

In your case, since you have a history of allergic reactions and are experiencing hives, it is understandable that you would want to manage your symptoms effectively. However, it is also wise to be cautious, especially in the first trimester when the fetus is undergoing critical development. The fact that your doctor has prescribed this medication suggests that they believe the benefits outweigh the risks in your situation.

Here are some additional considerations regarding the use of antihistamines during pregnancy:
1. Dosage and Frequency: You mentioned that your doctor advised taking up to three tablets a day, but you are currently only taking one. This cautious approach is commendable. It is always best to use the lowest effective dose for the shortest duration necessary to manage your symptoms.

2. Alternative Treatments: If you are concerned about the use of Dexchlorpheniramine, you might want to discuss alternative treatments with your healthcare provider. Non-pharmacological approaches, such as avoiding known allergens, using cool compresses on affected areas, and maintaining a cool environment, can sometimes help alleviate symptoms without the need for medication.

3. Monitoring Symptoms: Keep track of your symptoms and any potential triggers. If you notice that certain foods, like kiwi, are causing reactions, it may be beneficial to avoid them. Additionally, if your hives worsen or you experience other concerning symptoms, it is essential to seek medical advice promptly.

4. Consulting a Specialist: If you have ongoing concerns about the safety of this medication or your allergic reactions, consider consulting a maternal-fetal medicine specialist. They can provide more tailored advice based on your specific medical history and pregnancy.

5. Breastfeeding Considerations: If you plan to breastfeed after delivery, it's also worth discussing the implications of antihistamine use during that period, as some medications can pass into breast milk.

In summary, while Dexchlorpheniramine is classified as a Category B medication and is generally considered safe for use during pregnancy, it is crucial to use it under the guidance of your healthcare provider. Your cautious approach to medication use is wise, and maintaining open communication with your doctor will help ensure the best outcomes for both you and your baby. If you have any further concerns or questions, do not hesitate to reach out to your healthcare provider for personalized advice.

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