the Side Effects of Progesterone for Pregnancy Support - Pharmacology

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Inquiring about the side effects of medications for maintaining pregnancy?


Hello Doctor, I am currently over six weeks pregnant (with a heartbeat).
A few days ago, I experienced some brown spotting due to fatigue (it was not much, just enough to use a panty liner).
After intermittent bleeding for half a day, I went to the hospital.
The doctor said I have insufficient progesterone and administered a progesterone injection.
After the injection, I felt groggy; is this normal? Additionally, I was prescribed Utrogestan 100mg, a beige capsule to take one in the morning and one in the evening.
After taking it, I still feel particularly sleepy and groggy, and I also feel dizzy...
Is this normal? After taking the medication, I find it hard to concentrate at work...
I'm confused.
The bleeding has stopped, but I still experience light brown spotting if I engage in vigorous activities or have strong emotional reactions.
Could you please clarify this for me? Thank you.

penny, 20~29 year old female. Ask Date: 2017/10/04

Dr. Liao Huiling reply Pharmacology


Drowsiness is a side effect of Utrogestan.
As for your current symptoms and whether to continue the medication, please discuss this with your prescribing physician.

Reply Date: 2017/10/04

More Info


When it comes to the use of progesterone, particularly in the form of Utrogestan (micronized progesterone), during early pregnancy, it is essential to understand both its therapeutic benefits and potential side effects. Progesterone is a hormone that plays a crucial role in maintaining pregnancy, especially in the early stages. It helps prepare the uterine lining for implantation and supports the embryo's development. In cases where there is a concern about insufficient progesterone levels, supplementation can be beneficial and is often prescribed to prevent miscarriage.

In your case, experiencing brown spotting can be alarming, but it is not uncommon in early pregnancy, especially if it is minimal and not accompanied by severe cramping or bright red bleeding. The administration of progesterone injections and oral supplementation with Utrogestan is a common approach to manage such situations. The symptoms you are experiencing, such as drowsiness, dizziness, and difficulty concentrating, can be side effects of progesterone. These effects are generally due to the sedative properties of the hormone, which can lead to increased fatigue and a sense of lethargy.

It is important to note that while these side effects can be bothersome, they are typically not harmful to the fetus. However, if they significantly impact your daily activities or if you experience any new or worsening symptoms, it is crucial to communicate this with your healthcare provider. They may consider adjusting your dosage or exploring alternative options to manage your progesterone levels without causing excessive sedation.

In terms of the brown spotting you mentioned, it is essential to monitor the situation closely. If the spotting persists or worsens, or if you experience any additional symptoms such as severe abdominal pain or heavy bleeding, you should seek medical attention promptly. Your healthcare provider may want to perform an ultrasound to ensure that everything is progressing normally with the pregnancy.

Additionally, maintaining a healthy lifestyle during this time is vital. Ensure you are getting adequate rest, staying hydrated, and managing stress levels. Emotional well-being can also play a significant role in physical health during pregnancy, so finding ways to relax and reduce anxiety can be beneficial.

In summary, while the side effects of progesterone can be uncomfortable, they are generally manageable and not indicative of harm to the fetus. Your healthcare provider is your best resource for navigating these concerns, so keep an open line of communication with them regarding your symptoms and any changes you experience. Your health and the health of your baby are the top priorities, and with proper monitoring and care, you can work towards a healthy pregnancy.

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