Interactions Between Provera and Cefadroxil: What You Need to Know - Pharmacology

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Provera (medroxyprogesterone acetate) and the antibiotic Cefadroxil do not have any known significant drug interactions. However, it is always important to consult with a healthcare provider for personalized medical advice and to discuss any potential interactions based on individual health conditions and medications?


Hello, pharmacist.
Thank you for responding to question #129297.
Last week, I was taking the antibiotic Cefadroxil for a urinary tract infection, which I need to continue until this Thursday (the 19th).
However, I need to start taking Provera on Wednesday (the 18th) to delay my menstrual period this month.
I would like to know if these two medications can be taken together.
Will the antibiotic reduce the effectiveness of Provera? If I take them together, will my period still come, or could it be harmful to my body? If there are indeed adverse effects or if Cefadroxil reduces the efficacy of Provera, what would you recommend for proper usage? Should I stop taking the antibiotic first? I may need to take Provera due to my situation.
Thank you, pharmacist.

dra, 20~29 year old female. Ask Date: 2017/10/16

Dr. Liao Huiling reply Pharmacology


The results indicate that Cefadroxil may have a slight impact on the effectiveness of Provera; however, since the duration of co-administration is short, the effect may not be significant.
If there are concerns, it is advisable to consult a physician to evaluate whether a medication adjustment is necessary.

Reply Date: 2017/10/16

More Info


When considering the simultaneous use of Provera (medroxyprogesterone acetate) and Cefadroxil, it is essential to understand the potential interactions and effects of these medications on each other and the body. Provera is a synthetic form of the hormone progesterone, commonly used for various indications, including menstrual cycle regulation and hormone replacement therapy. Cefadroxil, on the other hand, is a cephalosporin antibiotic used to treat bacterial infections, including urinary tract infections.

Based on the available information, there is no significant evidence to suggest that Cefadroxil will drastically reduce the effectiveness of Provera. However, it is noted that there may be a slight interaction that could potentially affect Provera's efficacy. This interaction is not well-documented, and the clinical significance is likely minimal, especially since the duration of concurrent use is short. Therefore, while it is generally considered safe to take both medications together, it is always prudent to consult with a healthcare provider for personalized advice.

Regarding the concern about whether taking these medications together could lead to an unexpected onset of menstruation, it is important to note that Provera is designed to delay menstruation by maintaining elevated progesterone levels. If taken correctly, it should effectively delay the menstrual cycle. However, individual responses to hormonal medications can vary, and factors such as the timing of administration, dosage, and individual hormonal balance can influence outcomes. Therefore, while the risk of menstruation occurring while on Provera is low, it is not entirely eliminated.

If you are experiencing any side effects or have concerns about the combination of these medications, it is advisable to monitor your body's response closely. If you notice any unusual symptoms or if your menstrual cycle does not behave as expected, reaching out to your healthcare provider is crucial. They may suggest adjusting the timing of your medications or exploring alternative treatments if necessary.

In summary, while there is a possibility of a minor interaction between Provera and Cefadroxil, the overall risk of significant adverse effects or reduced efficacy appears low. It is essential to maintain open communication with your healthcare provider, especially when managing multiple medications. They can provide tailored advice based on your specific health needs and circumstances, ensuring that you can safely and effectively manage your conditions. Always prioritize your health and well-being by seeking professional guidance when in doubt about medication interactions.

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