Dry Eye Syndrome After Discontinuing Oral A-Retinoids - Dermatology

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Inquiry about dry eye syndrome related to A acid?


Hello Dr.
Wu, this issue is quite complex.
I stopped taking oral isotretinoin over three years ago (around 2014).
Initially, I experienced very dry eyes and dry skin, and it was difficult for me to tear up, but I had no issues driving, using the computer, or watching shows.
At that time, I didn't realize these were symptoms of dry eye syndrome.
This March, after staying up late to watch shows, my eyes became very uncomfortable, and the next day I woke up unable to open my eyes fully.
That’s when I went to see an ophthalmologist and learned that I have dry eye syndrome.

Now, I have some areas on my skin that are slightly swollen, and when pressed, they release a thin white substance.
Could this indicate that my facial sebaceous glands are blocked, which might be affecting my eyes and contributing to my dry eye syndrome? Additionally, since I haven't been resting properly, my dry eye condition has worsened.
If my skin becomes oilier, will that help improve the situation? If so, how can I increase the oiliness of my skin? Are there any other methods? Thank you, Dr.
Wu, for patiently reading this.

Chen Tongxue, 20~29 year old female. Ask Date: 2017/10/27

Dr. Wu Yuxin reply Dermatology


Oral isotretinoin may cause drier eyes, but whether your situation is directly related to this is a question you should discuss with your primary physician, or it may be advisable to have an eye specialist examine you.

Reply Date: 2017/10/27

More Info


Understanding Dry Eye Syndrome after discontinuing oral A-retinoids, such as Accutane, can be quite complex. Accutane is known for its effectiveness in treating severe acne, but it can also lead to various side effects, including dry eyes. This is primarily due to its impact on sebaceous glands, which are responsible for producing the oil component of tears. When these glands are affected, the tear film can become unstable, leading to symptoms of dry eye syndrome.

In your case, it seems that after discontinuing Accutane for over three years, you began to experience significant dry eye symptoms, particularly after periods of extended screen time. This is not uncommon, as the effects of Accutane on the body can persist long after the medication has been stopped. The fact that you initially did not recognize your symptoms as dry eye indicates that the condition can sometimes develop gradually and may not be immediately apparent.

The symptoms you describe, such as difficulty in keeping your eyes open after waking up and discomfort during activities like driving or watching TV, are classic signs of dry eye syndrome. Additionally, the mention of skin issues, such as small bumps that are white and can be pressed down, suggests that there may be some blockage of the sebaceous glands in your skin, which could indeed be related to your dry eye symptoms. Blocked sebaceous glands can lead to a decrease in the oil that is necessary for a healthy tear film, exacerbating dry eye symptoms.

As for your question about whether your skin becoming oilier could help improve your dry eye condition, the answer is somewhat nuanced. An increase in oil production in the skin could potentially lead to better lubrication of the eyes, as the oil from the skin can contribute to the overall health of the tear film. However, this is not a guaranteed solution, and it is essential to approach this issue holistically.

Here are some strategies that may help manage your dry eye symptoms:
1. Artificial Tears: Regular use of preservative-free artificial tears can help keep your eyes lubricated. These drops can provide immediate relief from dryness and discomfort.

2. Warm Compresses: Applying warm compresses to your eyes can help unblock any clogged oil glands, promoting better oil production and improving the quality of your tear film.

3. Omega-3 Fatty Acids: Incorporating omega-3 fatty acids into your diet, either through food sources like fish or through supplements, may help improve the function of the meibomian glands, which produce the oily layer of tears.

4. Environmental Modifications: Reducing exposure to dry air, using humidifiers, and taking regular breaks from screens can help alleviate symptoms.

5. Consulting with a Specialist: Since your symptoms are persistent and have been exacerbated by your history with Accutane, it may be beneficial to consult with an ophthalmologist or a specialist in dry eye disease. They can provide tailored treatments, which may include prescription medications or specialized devices like punctal plugs to reduce tear drainage.

6. Skin Care: For the skin issues you mentioned, consider consulting a dermatologist. They can provide treatments to help manage any blocked sebaceous glands and improve your skin's overall health.

In conclusion, while the relationship between skin oiliness and dry eye symptoms is complex, addressing both your ocular and dermatological concerns holistically is essential. Regular follow-ups with your healthcare providers can help you navigate these challenges effectively.

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