Dry Eye Syndrome: The Impact of Oral Contraceptives - Ophthalmology

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Dry eye syndrome and oral contraceptives?


Hello doctor, I have been experiencing dry eye syndrome for over three months (since March).
I have seen three ophthalmologists who prescribed artificial tears and eye gels, but my symptoms (dryness, soreness, and fatigue) have not improved significantly.
I have also stopped wearing contact lenses for nearly two months.
I especially feel intense soreness when pressing on my eyebrows (could this be caused by dry eyes?).
I started taking oral contraceptives in February and stopped in May; it seems that oral contraceptives can cause dry eye syndrome.
It has been over a month since I stopped taking the pills, but why haven't my symptoms improved?

Wuwu, 20~29 year old female. Ask Date: 2018/06/30

Dr. Cai Wenyuan reply Ophthalmology


Hello: Please minimize the use of electronic devices and allow your eyes to rest more.
Wishing you safety and health.
Sincerely, Dr.
Tsai Wen-Yuan, Director of the Ophthalmology Department, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2018/06/30

More Info


Dry Eye Syndrome (DES) is a multifactorial condition characterized by a loss of homeostasis of the tear film, leading to ocular symptoms and potential damage to the ocular surface. Your experience with dry eye symptoms, particularly after starting and then stopping oral contraceptives, raises important questions about the relationship between hormonal changes and dry eye symptoms.

Oral contraceptives (OCs) can influence tear production and ocular surface health due to their hormonal content, primarily estrogen and progesterone. These hormones can affect the lacrimal glands, which are responsible for tear production, and may lead to changes in the composition of tears. Some studies suggest that hormonal fluctuations can lead to decreased tear production, which may exacerbate dry eye symptoms. However, the exact mechanism by which OCs affect dry eye syndrome is not fully understood and can vary from person to person.

In your case, it is noteworthy that you began experiencing dry eye symptoms around the same time you started taking oral contraceptives. While it is possible that the hormones in the contraceptives contributed to your symptoms, it is also important to consider other factors that could be at play. For instance, environmental factors, screen time, and underlying health conditions can also contribute to dry eye syndrome.
The fact that you have seen multiple eye care professionals and have been prescribed artificial tears and gels without significant improvement suggests that there may be additional underlying issues. The strong pain you experience when pressing on your eyebrows could indicate that there is more than just dry eye at play. This discomfort may be related to inflammation or irritation of the ocular surface or surrounding tissues, which could be exacerbated by dry eye but may also indicate another condition.

Since you have stopped taking the oral contraceptives for over a month and have not seen improvement, it may be beneficial to explore other potential causes of your symptoms. Conditions such as meibomian gland dysfunction (MGD), blepharitis, or even autoimmune disorders could be contributing to your dry eye symptoms. A thorough examination by an eye care professional, possibly including tests for tear production and quality, could help clarify the situation.

In terms of management, if artificial tears and gels have not provided relief, there are other treatment options available. Punctal plugs, which block the tear drainage ducts, can help retain tears on the ocular surface. Additionally, prescription medications such as cyclosporine A (Restasis) or lifitegrast (Xiidra) may be considered to reduce inflammation and increase tear production.

It is also essential to maintain good eyelid hygiene and consider lifestyle modifications, such as reducing screen time, using a humidifier, and ensuring adequate hydration. If you suspect that your symptoms are related to hormonal changes, discussing this with your healthcare provider may provide further insights and alternative management strategies.

In conclusion, while oral contraceptives may have played a role in the onset of your dry eye symptoms, it is crucial to consider a comprehensive approach to diagnosis and treatment. Collaborating with both your eye care provider and possibly a healthcare professional specializing in hormonal health could lead to a more effective management plan for your dry eye syndrome.

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