Vaccine Side Effects vs. Common Cold in Infants - Pediatrics

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Side effects of the varicella (chickenpox) and measles vaccine?


Hello, Dr.
Hsiao: My baby turned 1 year old on December 8 and received the varicella and measles, mumps, rubella (MMR) combination vaccine on December 11.
Starting December 12, he began coughing and had trouble sleeping at night.
By December 13, he developed a runny nose, and his cough worsened.
His highest temperature so far has been 37.6 degrees Celsius.
I would like to know how to differentiate between vaccine side effects and a real cold.
The manual states that cold symptoms may appear 5 to 12 days after vaccination, and I am concerned that it might actually be a cold given the current weather.
If I assume it is a side effect and do not address it, could there be any consequences? Thank you for your response, doctor.

MOMO, 30~39 year old female. Ask Date: 2017/12/13

Dr. Xiao Kaiwen reply Pediatrics


The varicella, measles, rubella, and mumps combination vaccine is a live attenuated vaccine.
If there are side effects, they typically occur 5 to 12 days after vaccination.
Since your child is experiencing cold symptoms one or two days after vaccination, it is unlikely to be a side effect of the vaccine.
In clinical practice, cold symptoms are very rarely associated with these vaccines.
Therefore, it is more likely that your child has contracted a cold.
It is advisable to consult a pediatrician for appropriate evaluation and treatment.

Reply Date: 2017/12/13

More Info


When it comes to understanding the side effects of vaccines versus the common cold in infants, it is essential to recognize that both can present with similar symptoms, making it challenging for parents to differentiate between the two. In your case, your child received the varicella (chickenpox) and MMR (measles, mumps, and rubella) vaccines shortly before developing symptoms like coughing and a runny nose.

Vaccines, particularly live attenuated vaccines like the MMR, can indeed cause mild side effects that may resemble cold symptoms. These side effects typically occur within a few days to a couple of weeks after vaccination. Common vaccine-related symptoms can include mild fever, irritability, and respiratory symptoms such as a runny nose or cough. The timeline you mentioned, where symptoms began on the second day post-vaccination, aligns with the expected response to the vaccine. The vaccine's side effects usually resolve within a few days.

On the other hand, the common cold is caused by viral infections, which are prevalent, especially in young children. Symptoms of a cold can include coughing, nasal congestion, runny nose, and sometimes a mild fever. Colds can occur independently of vaccination, particularly during colder months when respiratory viruses are more common.

To differentiate between vaccine side effects and a true cold, consider the following:
1. Timing: Vaccine side effects typically manifest within a few days post-vaccination. If your child’s symptoms started shortly after the vaccination, they might be related to the vaccine.

2. Severity of Symptoms: Vaccine side effects are usually mild. If your child develops a high fever (over 101°F or 38.3°C), persistent cough, or significant distress, it may indicate a cold or another infection rather than a vaccine reaction.

3. Duration: Vaccine-related symptoms generally resolve within a few days. If symptoms persist beyond a week or worsen, it is advisable to consult a healthcare provider.

4. Accompanying Symptoms: Look for additional symptoms that may indicate a cold, such as significant fatigue, body aches, or a sore throat. If your child exhibits these symptoms, it may be more indicative of a viral infection.

5. Response to Treatment: If you administer supportive care (like fever reducers or fluids) and your child does not improve or worsens, this could suggest a need for further evaluation.

In your case, since your child has a mild fever (37.6°C) and is experiencing respiratory symptoms, it is reasonable to monitor the situation closely. Ensure your child stays hydrated and comfortable. If symptoms worsen or do not improve within a few days, or if you have any concerns about their health, it is always best to consult with a pediatrician for a thorough evaluation.

In summary, while it is common for children to experience mild symptoms after vaccination, it is crucial to remain vigilant and differentiate these from symptoms of a cold or other infections. Keeping a close eye on your child's symptoms and seeking medical advice when necessary will help ensure their health and well-being.

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