Preventive Vertebroplasty: Is It Right for Your Osteoporosis Risk? - Orthopedics

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Preventive bone cement injection


Dear Dr.
Lee,
My mother is currently 68 years old.
Recently, she underwent a bone density test, which revealed an average lumbar spine bone density value of -3.2 (T score).
Aside from mild hypertension, she does not have any other medical conditions.
Currently, she has not experienced any fractures or back pain.
My grandmother also had severe osteoporosis, which later led to multiple compression fractures in her lumbar spine, resulting in significant kyphosis.
Therefore, my mother is very concerned about potentially experiencing the same fate.
I would like to ask Dr.
Lee if, given this situation, prophylactic vertebroplasty is a viable option? Additionally, I would like to inquire about the clinical experience with the medication Prolia.
Thank you!

Ms. Wu, 40~49 year old female. Ask Date: 2018/01/15

Dr. Li Yongheng reply Orthopedics


Hello, I do not recommend performing prophylactic vertebroplasty.
This procedure is still considered invasive and carries risks, such as infection and cement leakage leading to nerve compression.
Denosumab (Prolia) is commonly used in clinical practice and is effective for treating osteoporosis.
However, since your mother does not have any fractures, she is not eligible for insurance coverage for Denosumab.

Reply Date: 2018/01/15

More Info


When considering preventive vertebroplasty for osteoporosis, especially in a patient like your mother, who has a T-score of -3.2, it's essential to weigh the benefits against the risks. Vertebroplasty is a minimally invasive procedure that involves injecting bone cement into a fractured vertebra to stabilize it and alleviate pain. However, its use as a preventive measure in patients without current fractures is still a topic of debate among medical professionals.

In your mother's case, her T-score indicates significant bone density loss, which places her at a higher risk for vertebral fractures. Given her family history of severe osteoporosis and resultant complications, it is understandable that she is concerned about her future. However, the decision to proceed with prophylactic vertebroplasty should be made cautiously. Currently, the procedure is typically reserved for patients who have already experienced a vertebral fracture and are suffering from pain as a result. The rationale is that injecting cement into healthy vertebrae may not provide the intended benefits and could potentially lead to complications, such as cement leakage or adjacent vertebral fractures due to increased stress on neighboring vertebrae.

Instead of vertebroplasty, it may be more beneficial for your mother to focus on non-invasive preventive measures. These include lifestyle modifications such as engaging in weight-bearing exercises, ensuring adequate calcium and vitamin D intake, and possibly starting medications that can help strengthen bone density. Medications like Prolia (denosumab) have been shown to be effective in reducing the risk of fractures in postmenopausal women with osteoporosis. Prolia works by inhibiting the activity of osteoclasts, the cells responsible for bone resorption, thereby helping to maintain or increase bone density. Clinical experience has shown that Prolia can significantly reduce the risk of vertebral and hip fractures, making it a viable option for patients with low bone density.

In summary, while your mother's situation warrants careful monitoring and proactive management of her osteoporosis risk, prophylactic vertebroplasty may not be the most appropriate course of action at this time. Instead, discussing the potential benefits of medications like Prolia with her healthcare provider, along with lifestyle changes to enhance bone health, may be the best approach to prevent future fractures and maintain her quality of life. Regular follow-ups and bone density assessments will also be crucial in managing her osteoporosis effectively.

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