Glaucoma: Concerns with Sancoba and Mikelan Eye Drops - Ophthalmology

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Glaucoma and the issues related to Sancoba and Mikelan eye drops?


Hello Doctor: I apologize for interrupting your busy schedule, and I appreciate your valuable time! I am a glaucoma patient and would like to ask the following questions:
1.
The package insert for Sancoba eye drops (0.02% Cyanocobalamin + additives benzalkonium chloride + boric acid + sodium borate) contains a warning indicating that glaucoma patients should use it with caution, but it does not explain why.
What are the specific precautions that should be taken?
2.
I am using the beta-blocker Mikelan eye drops (2% Carteolol Hydrochloride 20mg/ml) once a day.
Should I apply it in the morning upon waking or at night before bed for better effectiveness?
3.
Even with an intraocular pressure of around 18 mmHg, I often feel a sensation of pressure and pain.
Is this related to the intraocular pressure?
4.
During a fundus examination, a notch was observed.
Is this caused by glaucoma or is it congenital? Could the visual field loss be a result of this?
Thank you very much! Sincerely, the patient.

Mr. Huang, 50~59 year old female. Ask Date: 2018/01/19

Dr. He Jianxian reply Ophthalmology


1.
There should be no special effects.

2.
There should be no difference between morning and evening measurements.

3.
Your discomfort is likely unrelated to intraocular pressure and is probably due to eye fatigue.

4.
Some notches are congenital, while others are caused by glaucoma.
Based on your description, it is not possible to determine the cause; generally, monitoring changes in visual fields is sufficient.

Reply Date: 2018/01/19

More Info


Hello! Thank you for your thoughtful questions regarding glaucoma and the use of Sancoba and Mikelan eye drops. I appreciate your concerns, and I will do my best to provide you with comprehensive answers based on medical knowledge.

1. Sancoba (Cyanocobalamin) and Glaucoma: The warning on the Sancoba eye drops for glaucoma patients likely stems from the presence of benzalkonium chloride, a preservative that can cause ocular surface toxicity, particularly in patients with pre-existing conditions like glaucoma. This toxicity can exacerbate dry eye symptoms and potentially lead to further complications in patients with glaucoma, who may already have compromised ocular health. It is essential to monitor for any adverse reactions when using this medication, especially if you experience increased discomfort or changes in vision.

2. Mikelan (Carteolol Hydrochloride) Usage Timing: The timing of when to administer beta-blocker eye drops like Mikelan can vary based on individual circumstances and the prescribing physician's recommendations. Generally, it is advisable to follow the instructions provided by your eye care professional. Some studies suggest that administering these drops in the morning may be beneficial, as intraocular pressure (IOP) tends to be higher during the day. However, if you find that your IOP fluctuates significantly throughout the day, your doctor may recommend a different schedule. Consistency in timing is crucial for maintaining stable IOP levels.

3. IOP and Discomfort: Experiencing a sensation of pressure or pain in the eyes, even with an IOP reading of around 18 mmHg, can be concerning. It is important to understand that IOP is just one factor in glaucoma management. Other factors, such as the health of the optic nerve and the presence of other symptoms, can contribute to discomfort. Some patients may experience discomfort due to factors unrelated to IOP, such as dry eye syndrome or ocular surface disease. It is advisable to discuss these symptoms with your ophthalmologist, as they may need to adjust your treatment plan or investigate further.

4. Notch in the Optic Nerve and Visual Field Loss: The presence of a notch in the optic nerve head can be indicative of glaucoma, but it is not exclusively so. Some individuals may have anatomical variations that result in a notch without any pathological significance. However, if there is a correlation between the notch and visual field loss, it is essential to consider this in the context of your overall eye health. Regular visual field testing is crucial for monitoring any changes and determining the progression of glaucoma. Your ophthalmologist will be able to provide insights into whether the notch is a result of glaucoma or a congenital variation.

In summary, managing glaucoma requires a comprehensive approach that includes regular monitoring of IOP, assessment of optic nerve health, and addressing any symptoms you may experience. It is vital to maintain open communication with your eye care provider regarding any concerns or changes in your condition. They can tailor your treatment plan to best suit your needs and ensure optimal eye health. Thank you for your questions, and I wish you the best in your ongoing management of glaucoma!

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